TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC 50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer In Vitro TRPM4-IN-2 (NBA) (50 μM; 0-500 s) blocks the endogenous TRPM4 current...
Garland CJ, Smirnov SV, Bagher P, Lim CS, Huang CY, Mitchell R, Stanley C, Pinkney A, Dora KA: TRPM4 inhibitor 9-phenanthrol activates endothelial cell intermediate conductance calcium-activated potassium channels in rat isolated mesenteric artery. Br J Pharmacol 2015;172:1114-1123....
查看相关系列 TRP Channel (182) TRPM4 Channel blocker (8) TRPM4 Gating inhibitor (8) 神经元信号传导 (3338) 膜转运器/离子通道 (1836) Skip to the end of the images gallery Skip to the beginning of the images gallery 基本描述 别名 4-氯-2-[[[2-(2-氯苯氧基)乙酰基]氨基]苯甲酸 ...
NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss in mice.NMDAR/TRPM4-IN-2 has neuroprotective activity against NMDA-induced hippocampal neuronal cell death and mito...
描述 NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss in mice.NMDAR/TRPM4-IN-2 has neuroprotective activity against NMDA-induced hippocampal neuronal cell death and...
Here, we used whole-cell amphotericin-B perforated and inside-out single-channel patch-clamp techniques, and isometric DSM tension recordings to address the hypothesis that TRPM4 channels regulate DSM excitation-contraction coupling by examining the novel selective TRPM4 channel inhibitor 4-chloro-2-[...
We have shown recently that cytosolic ATP4– acts as a potent inhibitor of TRPM4 currents in inside-out patches, with half-maximal inhibition at ∼2 μm (3). However, robust TRPM4 currents can be measured in the whole-cell mode, even under conditions in which the free cytosolic ATP4...
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TRPM4 inhibitor 8 化合物 TRPM4 inhibitor 8 1353979-43-7 4-Hydroxyphenylglyoxylic Acid 化合物 4-Hydroxyphenylglyoxylic Acid 15573-67-8 Aranciamycin 化合物 Aranciamycin 72389-06-1 Antifreeze Polypeptide 6 (winter flounder) 化合物 Antifreeze Polypeptide 6 (winter flounder) 122604-16-4 CB-25 ...
Western blotting was routinely performed as previously reported [37]. Rodent brain tissues, sorted cells or BV2 cells were homogenized in RIPA lysis buffer (Cat. # P0013; Beyotime) containing protease inhibitor cocktail. After denatured in loading buffer, the samples were subjected to SDS-PAGE an...