TRPM4-IN-1 (CBA) 是一种阳离子通道 TRPM4 抑制剂, IC50值为1.5 μM。 产品性质 英文别名(English Synonym) TRPM4-IN-1 中文名称(Chinese Name) / 靶点(Target) / 通路(Pathway) Membrane Transporter/Ion Channel CAS号(CAS NO.) 351424-20-9 ...
英文名: TRPM4-IN-1描述: TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) 是一种有效的阳离子通道TRPM4选择性抑制剂,IC50为 1.5 μM。TRPM4-IN-1 在心脏病和前列腺癌中具有研究价值。体外活性: TRPM4-IN-1 在HEK293细胞中选择性地抑制过表达的TRPM4。在LNCaP细胞中,TRPM4-IN...
TRPM4-IN-1 英文名:TRPM4-IN-1 Cas号:351424-20-9 检测信息查询 货号规格货期库存价格会员价订购 140820513241-10mg98%2-3天0￥400 -+ 140820513241-25mg98%2-3天0￥800 -+ 140820513241-50mg98%2-3天0￥1500 -+ 偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体,下单前请联系客服。
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Sulfonylurea receptor 1 (SUR1) and transient receptor potential cation channel subfamily M member 4 (TRPM4) receptors play an important role in the pathogenesis of several neural injuries, such as neural edema, spinal cord damage, stroke, and neuronal damage in aSAH. This study aimed to ...
1-transient receptor potential M4 (SUR1-TRPM4) mediates microglial NLRP3-related inflammation following global brain ischemia. However, the role of SUR1-TRPM4 in RIBI remains unclear. Here, we found that whole-brain radiation induced up-regulation and assembly of SUR1-TRPM4, which further ...
The transient receptor potential melastatin 4 (TRPM4) channel contributes to disease severity in the murine experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis and to neuronal cell death in models of excitotoxicity and traumatic b
Transient receptor-potential, cation channel, subfamily M, member 4 (TRPM4) channels regulate a variety of physiological and pathological processes; however, their roles as functional channels under diverse conditions remain unclear. In this study, cytosolic protein tyrosine phosphatase non-receptor type...
However, the role of SUR1-TRPM4 in RIBI remains unclear. Here, we found that whole-brain radiation induced up-regulation and assembly of SUR1-TRPM4, which further activated the NLRP3 inflammasome in microglia and caused persistent neuroinflammation in mice. Blocking SU...
Knockdown of TRPM4 mediated by siRNA impaired proliferation and arrested the cell cycle at the G0/G1 phase in MLL-rearranged leukemia cells. We suggested that TRPM4 may be involved in the pathogenesis of MLL-rearranged leukemia through regulating the AKT/GLI1/Cyclin D1 pathway. The ...