综上,本研究阐明了lncRNA TRPM2-AS是胆囊癌血管生成中的关键促进分子,并证实IGF2BP2-TRPM2-AS/PABPC1-NUMB-NOTCH1是胆囊癌中一种新的促血管生成轴,这提示TRPM2-AS作为胆囊癌中新的且有前途的血管生成生物学标志物,为未来胆囊癌...
我们使用生物素标记的TRPM2-AS探针进行RAP实验,结果显示,在对照组中,过表达TRPM2-AS的水平显著提高了下拉产物中TRPM2-AS和NUMB的水平。 western blot也证实了PAPBC1是TRPM2-AS与NUMB之间的中介分子:下调PABPC1后,TRPM2-AS对NUMB蛋白表达的抑制作用消失。 因此,PABPC1对于TRPM2-AS与NUMB mRNA的相互作用是必不可...
In conclusion, this study suggests that TRPM2-AS could promote OS cell malignancy by sponging miR-15b-5p/PPM1D axis.doi:10.1080/15384101.2022.2033414Yudan YangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaQingqing Ma...
TRPM2 Functions as a Lysosomal Ca2 -Release Channel in β Cells doi:10.1126/scisignal.2000278TRPM2 is a Ca2 -permeable cation channel that is specifically activated by adenosine diphosphoribose (ADPR). Channel activation in the plasma membrane leads to Ca2 influx and...
Long noncoding RNAs (lncRNAs) are emerging as important regulators of tumorigenesis and are frequently dysregulated in cancers. Here, we identify a critical lncRNA TRPM2-AS which is aberrantly expressed in gastric cancer (GC) tissues by screening The Cancer Genome Atlas Program(TCGA) database of...
TRPM2 is involved in regulation of metabolism in diabetes (insulin secretion, β-cell injury, and insulin resistance), and obesity. It has a role in inflammation, immunity, and cancer. Modulation of TRPM2 may be able to ameliorate a number of these disease processes as well as those ...
浙江大学 Zhejiang University TRPM2 Channel as a drug target for treating stroke damage 讲座论坛 0 2018-01-12 15:40 启真酒店四楼舜水厅 查看专业相关机会 药学
In conclusion, TRPM2-AS promotes OC cell viability and proliferation while enhancing cell apoptosis through interaction with miR-6764-5p to regulate TRPM2 level.doi:10.1186/s13008-024-00130-0Zhu, WeiMao, ShiqinJiang, JuanBioMed CentralCell Division...
细胞增殖凋亡目的探讨长链非编码RNA(lncRNA)瞬时受体电位通道M2反义RNA(TRPM2-AS)对耐奥沙利铂(L-OHP)的结直肠癌细胞增殖和凋亡的影响及可能机制.方法采用L-OHP浓度递增处理结直肠癌细胞HCT-8,获得L-OHP耐药细胞HCT-8/L-OHP,RT-qPCR法分别检测HCT-8和HCT-8/L-OHP细胞中TRPM2-AS与miR-22-3p表达.分别...
Knockdown of TRPM2 inhibited OV cell proliferation and promoted apoptosis. Overall, TRPM2 has relevance to an immunosuppressive tumor microenvironment by modulating macrophage. It could serve as a powerful biomarker for tumor screening and prognosis, and a potential therapeutic target for ...