TrkBF616A mice, which possess a mutation that renders TrkB kinase activity susceptible to rapid inhibition by 1NMPP1, were treated at 6, 18 or 24 months of age with vehicle or 1NMPP1 for 7 days. Immunofluorescence intensity was measured to determine LC3 and p62 expression in choline ...
E2 effects on synaptic responses were also absent in conditional β1-integrin knockouts, and with inhibition of matrix metalloproteinases, extracellular enzymes that generate integrin ligands. We propose that E2, acting through estrogen receptor-β, transactivates synaptic TrkB and β1-integrin, and ...
Accordingly, pharmacological inhibition of PP1 by okadaic acid (OA) prevented mutant huntingtin striatal cell death induced by NMDA and BDNF. Altogether, our findings demonstrate that the p75NTR/TrkB imbalance induced by mutant huntingtin in striatal cells associated with the aberrant activity of PP1...
Caspase inhibition selectively reduces the apoptotic component of oxygen-glucose deprivation-induced cortical neuronal cell death Mol. Cell. Neurosci., 9 (1997), pp. 159-169 View PDFView articleView in ScopusGoogle Scholar Grimes et al., 1996 M.L. Grimes, E.C. Reattie, E.C. Yuen, D.E....
The rapid AD effect of ketamine (KET) is attributed to inhibition of NMDA-type glutamate receptors (Abdallah et al., 2015; Berman et al., 2000; Zarate et al., 2006). However, 2R,6R-hydroxynorketamine (R,R-HNK), a KET metabolite with AD-like activity, exhibits low affinity to NMDA ...
inhibited only in trkB plus PC12 cells treated with BDNF plus test agent compared to trkB plus PC12 cells exposed to BDNF, and there should be little or no inhibition of sprouting of trkB-minus PC12 cells treated with NGF plus test agent relative to trkB-minus PC12 cells treated with ...
Consistent with these findings, mtDNA copy number was decreased following TrkB kinase inhibition by 1NMPP1. We conclude that inhibition of TrkB kinase by 1NMPP1 reduces PGC1a-mediated mitochondrial biogenesis in rat cervical ventral horn.Supported by NIH grants AG44615 and HL146114.This is the...
The effects of 1NMPP1 administration were due to inhibition of TrkB F616A , because the performance of wild-type mice was unaffected by administration of the compound during either phase. These data indicate that BDNF or NT4 signaling through TrkB receptors is required for the acquisition of ...
Inhibition of TrkB kinase activity had no effect on pre-synaptic or post-synaptic terminal volume in DIAm, EDLm, and SOLm. Similarly, the overlap of pre- and post-synaptic structures and the proportion of denervated NMJs did not change with 1NMPP1 treatment in all muscle types. The ...
TrkB inhibition by GNF-4256 slows growth and enhances chemotherapeutic efficacy in neuroblastoma xenografts. Cancer Chemother Pharmacol. 2015;75(1):131-141.Croucher JL, Iyer R, Li N, Molteni V, Loren J, Gordon WP, et al. TrkB inhibition by GNF-4256 slows growth and enhances chemotherapeutic ...