TrkB and TrkC agonist; brain penetrant 6037 2 Citations Show Size & Price HIOC Selective TrkB receptor agonist; neuroprotectant 5961 1 Citation Show Size & Price PF 06273340 Potent and selective pan-Trk inhibitor; peripherally restricted 6115 1 Citation 1 Review Show Size & Price page...
NMDAR-dependent cortical neuronal death is disrupted by a peptide mimicking the NR2B PDZ ligand (TAT-NR2B9c)8. PSD-95 also links the kainate receptor (GRIK2) with c-Jun-N-terminal kinase (JNK) activation9, and a peptide designed against the C-terminus of GRIK2, Tat-GluR6-9c, showed a...
A monoclonal antibody TrkB receptor agonist as a potential therapeutic for Huntington’s disease PLoS ONE, 9 (2014) Google Scholar Traub et al., 2017 S. Traub, H. Stahl, H. Rosenbrock, E. Simon, L. Florin, L. Hospach, S. Hörer, R. Heilker Pharmaceutical characterization of tropomyosi...
Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity resembling the effects of clinically approved antidepressants. We recently reported that pharmacologically diverse antidepressants, including fluoxetine and ketamine, act by binding to TrkB, the receptor for BDNF. Here we ...
Accumulating evidence shows that brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB) significantly decrease early in Alzheimer’s disease (AD). However, it remains unclear whether BDNF/TrkB reductions may be mech
The formyl peptide receptor 2 (ALX/FPR2), a G-protein-coupled receptor, has been implicated in resolving inflammation, making its agonist, Resolvin D1 (RvD1), a potential therapeutic agent. Previous studies suggest that RvD1 alleviates neuropathic pain via anti-inflammatory effects, but its ...
目的探讨氟暴露对小鼠海马神经元细胞(HT22细胞)微小核糖核酸(microRNA,miRNA,miR)-204、脑源性神经营养因子(BDNF)、酪氨酸激酶B(TrkB)表达的影响。 方法将HT22细胞暴露于0(对照)、2、4、6、8、10 mg/L氟化钠(NaF)。培养24 h后,CCK-8法检测细胞活性,根据细胞存活率结果,选取0.0(对照)、2.5、5.0、10.0 mg...
To identify the receptor on which BDNF acts and the cell-type that expresses the receptor, we deleted either TrkB or p75NTR in PCs or CFs. Our results show that BDNF derived from PCs retrogradely acts on TrkB on CFs and facilitate elimination of CF synapses from the PC soma after P16. ...
which requires MF plasticity. MF-LTP is an NMDA receptor-independent form of LTP that is expressed presynaptically and depends upon local BDNF/TrkB signaling11. Accordingly, we found that SIPA1L2 directly binds to TrkB and application of a TAT-peptide encompassing the binding region for TrkB in...
mBDNF is known to bind to receptor tyrosine kinase TrkB as a high-affinity receptor and to p75 neuroptophin receptor (p75NTR) as a low-affinity receptor18,19. proBDNF primarily binds to p75NTR, but it can also bind to TrkB13,20. SCIENTIFIC REPORTS | 3 : 3185 | DOI: 10.1038/srep...