Rose CR, Blum R, Pichler B, Lepier A, Kafitz KW, Konnerth A (2003) Truncated TrkB-T1 mediates neurotrophin-evoked cal- cium signalling in glia cells. Nature 426:74-78Rose CR, Blum R, Pichler B, et al. Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells. ...
NT-4是否会影响人卵子成熟和发育潜能,及不同亚型TrkB受体在其中是否发挥不同作用,目前尚无相关研究。因此本研究拟探索人卵泡液中NT-4水平及卵丘颗粒细胞中TrkB-fl和TrkB-t1表达量与卵子发育潜能的关系,为进一步了解影响卵子发育的机制,及探索其在IVF/ICSI治疗中的应用提供研究基础。 研究方法 纳入2020年5月至2020...
结果抑制BDNF/TrkB.T1通过降低背根神经节ASIC3信号转导缓解RTX所致带状疱疹后神经痛通 路实验概括一、RTX促进DRGs中ASIC3和TrkB.T1的表达二、抑制ASIC3减轻机械性疼痛并降低TRAF6信号转导三、抑制ASIC3降低DRGS神经元的高兴奋性四、抑制...
Collectively, excitotoxicity results in a decrease of TrkB-FL, the production of truncated TrkB-FL and the upregulation of TrkB-T1. A similar neuro-specific increase of the TrkB-T1 isoform is also observed in stroke patients. A lentivirus designed for both neuro-specific TrkB-T1 interference ...
Neurotrophin receptors TrkB.T1 and p75 doi:10.1111/j.1460-9568.2010.07460.xEuropean Journal of NeuroscienceMichaelsen, K.Zagrebelsky, M.Berndt‐Huch, J.Polack, M.Buschler, A.Sendtner, M.Korte, M.
Truncated trkB.T1 (T1) neurotrophin receptor inhibits full-length trkB.TK+ (TK+) signaling. At least two possible mechanisms have been proposed for this action: T1 could trap the ligand or function as a dominant negative receptor. To differentiate between these possibilities we have studied surviv...
在转基因的老鼠overexpressing里(i)TrkB全长或者(ii)削去BDNF的TrkB-T1 受体。 翻译结果3复制译文编辑译文朗读译文返回顶部 在转基因小鼠超量表达的全长 TrkB (i) 或 (ii) 截断源性神经营养因子受体 TrkB T1。 翻译结果4复制译文编辑译文朗读译文返回顶部 ...
In the inherited ALS G93A SOD1 animal model, deletion of the BDNF receptor TrkB.T1 delays spinal cord motoneuron cell death and muscle weakness through an unknown cellular mechanism. Here we show that TrkB.T1 is expressed ubiquitously in the spinal cord and its deletion does not change the ...
为了确定是否这样的脑源性神经营养因子的增加,可能会影响通过的TrkB受体海马癫痫,我们审查的后果(i)增加或(ii)减少对癫痫的TrkB信号转基因小鼠的过度表达(我),TrkB的全长或(II )截断的TrkB - T1 BDNF的受体。 翻译结果2复制译文编辑译文朗读译文返回顶部 ...
A truncated isoform of the receptor, TrkB.T1, lacks the intracellular kinase domain of the full length receptor and is up-regulated in multiple CNS injury models. Such up-regulation is associated with hyperpathic pain, and TrkB.T1 inhibition reduces neuropathic pain in various experimental ...