Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells. Nature. 426:74-78.Rose, C.R., Blum, R., Pichler, B., Lepier, A., Kafitz, K.W., Konnerth, A., 2003. Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glial cells. Nature 426, 74-78....
结果抑制BDNF/TrkB.T1通过降低背根神经节ASIC3信号转导缓解RTX所致带状疱疹后神经痛通 路实验概括一、RTX促进DRGs中ASIC3和TrkB.T1的表达二、抑制ASIC3减轻机械性疼痛并降低TRAF6信号转导三、抑制ASIC3降低DRGS神经元的高兴奋性四、抑制...
在转基因的老鼠overexpressing里(i)TrkB全长或者(ii)削去BDNF的TrkB-T1 受体。 翻译结果3复制译文编辑译文朗读译文返回顶部 在转基因小鼠超量表达的全长 TrkB (i) 或 (ii) 截断源性神经营养因子受体 TrkB T1。 翻译结果4复制译文编辑译文朗读译文返回顶部 在转基因老鼠overexpressing的(i)trkb全长度或(ii)被截断...
Truncated trkB.T1 (T1) neurotrophin receptor inhibits full-length trkB.TK+ (TK+) signaling. At least two possible mechanisms have been proposed for this action: T1 could trap the ligand or function as a dominant negative receptor. To differentiate between these possibilities we have studied surviv...
We have recently demonstrated that similarly to findings in AD brains, the ratio between the truncated TrkB.T1 and full-length TrkB.TK receptors is increased in the common APPswe/PS1dE9 (APP/PS1) mouse model of AD (Kemppainen et al., 2012). Functionally this changed ratio affects the spati...
In the inherited ALS G93A SOD1 animal model, deletion of the BDNF receptor TrkB.T1 delays spinal cord motoneuron cell death and muscle weakness through an unknown cellular mechanism. Here we show that TrkB.T1 is expressed ubiquitously in the spinal cord and its deletion does not change the ...
A truncated isoform of the receptor, TrkB.T1, lacks the intracellular kinase domain of the full length receptor and is up-regulated in multiple CNS injury models. Such up-regulation is associated with hyperpathic pain, and TrkB.T1 inhibition reduces neuropathic pain in various experimental ...
A truncated isoform of the receptor, TrkB.T1, lacks the intracellular kinase domain of the full length receptor and is up-regulated in multiple CNS injury models. Such up-regulation is associated with hyperpathic pain, and TrkB.T1 inhibition reduces neuropathic pain in various experimental ...
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