Rose CR, Blum R, Pichler B, Lepier A, Kafitz KW, Konnerth A (2003) Truncated TrkB-T1 mediates neurotrophin-evoked cal- cium signalling in glia cells. Nature 426:74-78Rose CR, Blum R, Pichler B, et al. Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells. ...
结果抑制BDNF/TrkB.T1通过降低背根神经节ASIC3信号转导缓解RTX所致带状疱疹后神经痛通 路实验概括一、RTX促进DRGs中ASIC3和TrkB.T1的表达二、抑制ASIC3减轻机械性疼痛并降低TRAF6信号转导三、抑制ASIC3降低DRGS神经元的高兴奋性四、抑制...
用ELISA检测卵泡液中NT-4浓度,实时荧光定量PCR检测卵丘颗粒细胞中TrkB受体两种不同亚型TrkB-fl和TrkB-t1的表达水平,分析与卵子成熟、受精和胚胎发育的关系。 (3)主要结局:卵泡液中NT-4浓度与正常受精数(rs=0.250, P=0.048)、可利用胚胎数(rs=0.320, P=0.011)、优质胚胎数(rs=0.327, P=0.009)和优质囊胚数(...
Neurotrophin receptors TrkB.T1 and p75 doi:10.1111/j.1460-9568.2010.07460.xEuropean Journal of NeuroscienceMichaelsen, K.Zagrebelsky, M.Berndt‐Huch, J.Polack, M.Buschler, A.Sendtner, M.Korte, M.
Mechanistically, hnRNPU deficiency stimulated the expression of a truncated isoform of TrkB (TRKB-T1) that promotes inflammatory signaling in hepatocytes and stress-induced cell death. Brain-derived neurotrophic factor treatment reduced membrane TRKB-T1 protein and protected mice from diet-induced NASH. ...
然而,使用TrkB激动剂治疗可导致TrkB或促凋亡的p75NTR和截断的TrkB- t1受体的广泛有害激活,从而降低其疗效。尽管广泛的TrkB激活已被报道提供神经保护,但BDNF模拟物通过AMPAR受体的“缩小”来阻断长时程增强,或者不加选择地稳定活跃和不活跃的突触以阻碍认知。PDZ3拮抗剂促进突触可塑性,对Angelman综合征起到治疗作用和...
TrkB.T1在成人大脑中缺乏TrkB.FL的非神经元细胞中大量表达。TrkB.T1和TrkB.T2同源异构体受体的生理功能尚不清楚,但有人提出它们可能具有至少两个主要功能,即作为配体捕获分子调节神经营养因子的局部可用性,或通过异二聚化反应作为神经营养因子的显性负性受体。最近的研究强调了截短型受体在一些与发育、记忆和损伤模式...
卵丘颗粒细胞中TrkB-t1的高表达与卵子发育潜能受损有关。 关键词:神经营养因子-4;酪氨酸相关激酶B受体;卵泡液;卵丘颗粒细胞;卵子质量 Abstract:【Objective】To investigate whether the neurotrophin-4 (NT-4) in human follicular fluid ...
Truncated trkB.T1 (T1) neurotrophin receptor inhibits full-length trkB.TK+ (TK+) signaling. At least two possible mechanisms have been proposed for this action: T1 could trap the ligand or function as a dominant negative receptor. To differentiate between these possibilities we have studied surviv...