differentiation of distinct cell populations (1). TRKB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway (2). Signalling through TRKB leads to cell differentiation. Mutations in the TRKB gene have been associated with obesity and ...
Temporal lobe epilepsyEpileptogenesisOBJECTIVE: The NTRK2 gene encodes a member of the neurotrophic tyrosine kinase receptor family known as TrkB. It is a membrane-associated receptor with signaling and cellular differentiation properties that has been involved in neuropsychiatric disorders, including ...
3. Skaper SD. The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors.Cns Neurol Disord-Dr.2008;7:46–62. 4. Gatalica Z, Xiu J, Swensen J, Vranic S. Molecular characterization of cancers with NTRK gene fusions.Modern Pathol.2019...
该基因编码神经营养性酪氨酸受体激酶(NTRK)家族的一个成员。这种激酶是一种膜结合受体,通过神经营养素结合,磷酸化自身和MAPK途径的成员。通过这种激酶的信号传导导致细胞分化。这种基因的突变与肥胖和心境障碍有关。选择性剪接导致多个转录变体。This gene encode
Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene. 仅用于科研。不用于诊断过程。未经明确授权不得转售。
Entrez Gene:4915 Swiss Prot:Q16620 Source:KLH conjugated synthetic peptide derived from human NTRK2:401-500/822 Purification:affinity purified by Protein A Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repe...
Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene. 仅用于科研。不用于诊断过程。未经明确授权不得转售。
(1990). "The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain". Cell 61: 647–656. doi:10.1016/0092-8674(90)90476-U. PMID 2160854. S. P. Squinto et al. (1991). "trkB encodes a functional receptor for brain-derived ...
The TrkB receptor is critical for the control of energy balance, as mutations in its gene () lead to hyperphagia and severe obesity. The main neural substrate mediating the appetite-suppressing activity of TrkB, however, remains unknown. Here, we demonstrate that selectivedeletion within ...
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