differentiation of distinct cell populations (1). TRKB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway (2). Signalling through TRKB leads to cell differentiation. Mutations in the TRKB gene have been associated with obesity and ...
TrkB gene expression and DNA methylation state in Wer- nicke area does not associate with suicidal behavior. J. Affect. Disord. 135, 400-404.Keller S, Sarchiapone M, Zarrilli F, Tomaiuolo R, Carli V, Angris- ano T, et al. TrkB gene expression and DNA methylation state in Wernicke...
3. Skaper SD. The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors.Cns Neurol Disord-Dr.2008;7:46–62. 4. Gatalica Z, Xiu J, Swensen J, Vranic S. Molecular characterization of cancers with NTRK gene fusions.Modern Pathol.2019...
该基因编码神经营养性酪氨酸受体激酶(NTRK)家族的一个成员。这种激酶是一种膜结合受体,通过神经营养素结合,磷酸化自身和MAPK途径的成员。通过这种激酶的信号传导导致细胞分化。这种基因的突变与肥胖和心境障碍有关。选择性剪接导致多个转录变体。This gene encode
The mouse neurotrophin receptor trkB gene is transcribed from two different promoters. Biochim Biophys Acta. 1999; 1446(1-2):24-34. Epub 1999/ 07/09... PM Barettino - 《Biochimica Et Biophysica Acta International Journal of Biochemistry & Biophysics》 被引量: 0发表: 1999年 Activation of the...
也可以通过基因改组(gene-shuffling)、噬菌体展示、大肠杆菌展示、核糖体展示、mRNA展示、蛋白质片段互补或RNA-肽筛选产生抗体。用于设计和产生人源化和人的抗体及其衍生物的方法被描述在,例如,美国专利7,005,504、6,800,738、6,407,213、6,054,297、6,331,415,和5,750,373(Genentech);美国专利6,833,268、...
Entrez Gene:4915 Swiss Prot:Q16620 Source:KLH conjugated synthetic peptide derived from human NTRK2:401-500/822 Purification:affinity purified by Protein A Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repe...
Gene ID (NCBI)4915 RRIDAB_2155156 ConjugateUnconjugated FormLiquid Purification MethodAntigen affinity purification Storage BufferPBS with 0.02% sodium azide and 50% glycerol pH 7.3. Storage ConditionsStore at -20°C. Stable for one year after shipment.Aliquoting is unnecessary for -20oC storage.20...
recovery。FurthermoretheleverofBDNF.TrkBgeneandproteinexpressioninthegroupof Chinesemedicineatthetimepointof12hrecoveryand24hweresignificantly higher than in mode1 group . Conclusion :BD NF and its reeeptm‘TrkB are involved in the repair process of ...
(P=0.005) and the expression of TrkB-t1 gene in CCs (P=0.049).【Conclusion】FF NT-4 level was positively associated with oocyte developmental competence, and it might play an important role in the development of oocytes...