CyclotropinB is a cyclic peptide composed of 11 amino acids (disulfide linked to a ring), which is an efficient and selective TrkB inhibitor that does not alter the binding of BDNF. CyclotropinB can non competitively inhibit BDNF induced TrkB activity, with an IC50 value of 0.30 nM. Cyclo...
GNF 5837 Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC 4559 3 Citations Show Size & Price Cyclotraxin B TrkB receptor antagonist 5062 2 Citations Show Size & Price LM22B 10 TrkB and TrkC agonist; brain penetrant 6037 2 Citations Show Size & Price HIOC Selective TrkB ...
Our data using TrkB inhibitor (K252a), TrkB siRNA and TrkB/ neurons demonstrated that TrkB inhibition suppresses NRG1-induced NR2B activation in neurons. We found that NRG1 stimulation leads to GABA A receptor-mediated TrkB activation. Co-immunoprecipitation and proximity ligase assay showed that ...
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Tyrphostin AG 879物理化学性质：Tyrphostin AG 879详细介绍：Tyrphostin AG 879参考文献：[1]. Rende M et al. Role of nerve growth factor and its receptors in non-nervous cancer growth: efficacy of a tyrosine kinase inhibitor (AG879) and neutralizing antibodies antityrosine kinase receptor A and ...
(1 mg; maintains E2 levels equivalent to those found in pre-menopausal women; Supplementary Fig.1a), (ii) placebo (OVX), or (iii) placebo mice additionally treated with aromatase-inhibitor letrozole (OVX + Letrozole) to block peripheral E2-synthesis. Two days post endocrine initiation,...
Nature 426: 74–78. PMID 14603320. K. Ohira et al. (2005). "A truncated tropomyosin-related kinase B receptor, T1, regulates glial cell morphology via Rho GDP dissociation inhibitor 1". Journal of Neuroscience 25: 1343–1353. PMID 15703388....
Transfected T1 completely inhibited survival by BDNF or constitutive trkB kinase activity in PC12-trkB cells similarly to tyrosine kinase inhibitor K252a. In addition, T1 coimmunoprecipitated with TK+ and inhibited its autophosphorylation by BDNF. These data suggest that truncated T1 inhibits TK+ ...
Cocco E, Scaltriti M, Drilon A (2018) NTRK fusion-positive cancers and TRK inhibitor therapy. Nat Rev Clin Oncol 15(12):731–747 Article CAS PubMed PubMed Central Google Scholar Yuzugullu H, Von T, Thorpe LM, Walker SR, Roberts TM, Frank DA, Zhao JJ (2016) NTRK2 activation coop...