Trk inhibitor attenuates the BDNF/TrkB-induced protection of neuroblastoma cells from etoposide in vitro and in vivo. Cancer Biol. Ther. 2015, 16, 477-483. [CrossRef] [PubMed]Li, Z., Zhang, Y., Tong, Y., Tong, J. & Thiele, C. J. Trk inhibitor attenuates the BDNF/TrkB-induced ...
CyclotropinB is a cyclic peptide composed of 11 amino acids (disulfide linked to a ring), which is an efficient and selective TrkB inhibitor that does not alter the binding of BDNF. CyclotropinB can non competitively inhibit BDNF induced TrkB activity, with an IC50 value of 0.30 nM. Cyclo...
Methods dependent breast cancer cells in mice, and is within serum-levels in pre-menopausal women (~50–150 pg/ml, Supplementary Fig.1a). Letrozole, an aromatase inhibitor known to cross the BBB [64], was diluted in 0.3% hydroxyl-propyl cellulose at 0.2 mg/ml and injected subcutaneou...
inib, while displaying similar potency against TRKA, TRKB, and TRKC WT kinases, was more active than other FDA approved or clinically tested 1st- (larotrectinib) and next-generation (selitrectinib and repotrectinib) TRK inhibitors against most TRK inhibitor resistance mutations (13 out of 18...
GNF 5837 Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC 4559 3 Citations Show Size & Price Cyclotraxin B TrkB receptor antagonist 5062 2 Citations Show Size & Price LM22B 10 TrkB and TrkC agonist; brain penetrant 6037 2 Citations Show Size & Price HIOC Selective TrkB ...
Truncated trkB.T1 is dominant negative inhibitor of trkB.TK+-mediated cell survival. Haapasalo A,Koponen E,Hoppe E,Wong G,Castren E.Truncated trkB .T1 is dominant negative inhibitor of trkB.TK+-mediated cell survival. Biochemical and ... A Haapasalo,E Koponen,E Hoppe,... - 《Biochem ...
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increased. Also, we found that there is no difference between CUMS and vehicle group. However, the advancing effect of XYS on synapse were blocked after hippocampal microinjection trkB inhibitor K252a, which further proves that XYS raise core synaptic protein may be through BDNF/trkB signal. BDNF...
有超过2.64亿名患者,有效的治疗手段除了心理治疗,更为直接的干预方式还有药物治疗,所以针对抗抑郁的药物也层出不穷,比如传统的三环类抗抑郁药(tricyclic antidepressant, TCA)、选择性5-羟色胺再摄取抑制剂(serotonin selective reuptake inhibitors,SSRIs)、单胺氧化酶抑制剂(monoamine oxidase inhibitor,MAOI)以及速效...
Cocco E, Scaltriti M, Drilon A (2018) NTRK fusion-positive cancers and TRK inhibitor therapy. Nat Rev Clin Oncol 15(12):731–747 Article CAS PubMed PubMed Central Google Scholar Yuzugullu H, Von T, Thorpe LM, Walker SR, Roberts TM, Frank DA, Zhao JJ (2016) NTRK2 activation coop...