Of interest, autophagy dysfunction is emerging as one of the main putative targets of ALS therapy. A tune regulation of this cleansing process is affordable by a proper stimulation of TRPML1, one of the main lysosomal channels. However, TRPML1 activation by PI(3,5)P2 has low open ...
Paradoxically, treatment with NaAsO2 causes robust JIP4-dependent clustering of lysosomes at the cell center7. This may be explained by recent observations showing that JIP4 phosphorylation following oxidative stress induces its interaction with the TRPML1/ALG2 complex, which also mediates dynein-...