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predicted by PrediXcan method [6],from a normalized expression value, that is adjusted for sex, the top 3 principal components (derived from genotype data) and the top 15 PEER factors [103], using the normalization procedures introduced in the PrediXcan paper: ...
contact corresponding authors for further information. Trait-associated variants were collected from the EBI GWAS Catalog (https://www.ebi.ac.uk/gwas/, accessed on 21 November 2016), the NIH GWAS Catalog (now hosted by the EBI GWAS Catalog,https://www.ebi.ac.uk/gwas/) and Immunobase (htt...
(highest black points) shows the most significant enrichment is for kidney samples, which are highly ranked for the top 1000 CpGs associated with eGFR.bFORGE2 analysis for eGFR SNPs from GWAS catalog: thexaxis indicates tissues/cell type samples used in the analysis; theyaxis shows FORGE2 ...
Genome-wide association studies (GWAS) have identified common variants associated with metabolic dysfunction-associated steatotic liver disease (MASLD). However, rare coding variant studies have been limited by phenotyping challenges and small sample siz
A gene-based association method for mapping traits using reference transcriptome data. Nat Genet. 2015;47(9):1091–8. 7. Li B, Verma SS, Veturi YC, Verma A, Bradford Y, Haas DW, Ritchie MD. Evaluation of PrediXcan for prioritizing GWAS associations and predicting gene expression. In: ...
The results of the present study confirm that epistasis has an important role in the genetic architecture of complex phenotypes and imply that this approach may be of relevance to other eQTL and GWAS data sets. Such studies could also benefit from samples that are ethnically more homogeneous. ...