Theoretical basis of admixture GWAS study designs. (a)Populations 1 and 2 are two parental populations in which there has been no gene flow historically. When these populations interbreed the subsequent F1 population includes heterozygotes. Over the course of 5 or 10 generations the chromosome of ...
Next, we compared the allele frequencies (AF) and effect sizes (BETA) of replicated SNPs in our data to those previously reported in the GWAS catalog (Fig. 2). We observed moderate correlation of allele frequencies (BMI-unadjusted, R2 = 0.66; BMI-adjusted, R2 = 0.64) with those...
A gene-based association method for mapping traits using reference transcriptome data. Nat Genet. 2015;47(9):1091–8. 7. Li B, Verma SS, Veturi YC, Verma A, Bradford Y, Haas DW, Ritchie MD. Evaluation of PrediXcan for prioritizing GWAS associations and predicting gene expression. In: ...
The results of the present study confirm that epistasis has an important role in the genetic architecture of complex phenotypes and imply that this approach may be of relevance to other eQTL and GWAS data sets. Such studies could also benefit from samples that are ethnically more homogeneous. ...
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(highest black points) shows the most significant enrichment is for kidney samples, which are highly ranked for the top 1000 CpGs associated with eGFR.bFORGE2 analysis for eGFR SNPs from GWAS catalog: thexaxis indicates tissues/cell type samples used in the analysis; theyaxis shows FORGE2 ...
METHODS: Using the PRISMA guideline, we searched PubMed and NHGRI- EBI GWAS catalog for stroke studies from 2007 till May 2017. RESULTS: We included 31 studies. The major challenge is that the few validated variants could not account for the full genetic risk of stroke and have not been ...
contact corresponding authors for further information. Trait-associated variants were collected from the EBI GWAS Catalog (https://www.ebi.ac.uk/gwas/, accessed on 21 November 2016), the NIH GWAS Catalog (now hosted by the EBI GWAS Catalog,https://www.ebi.ac.uk/gwas/) and Immunobase (htt...
To evaluate the effect of the two types of reference panels in imputing populations absent from the cosmopolitan panel, we performed transethnic fine mapping with GWAS data from three ancestry groups in Asia, consisting of East Asian Han Chinese, Southeast Asian Malays and South Asian Indians ...