OR or BETA*: Reported odds ratio or beta-coefficient associated with strongest SNP risk allele. Note that if an OR <1 is reported this is inverted, along with the reported allele, so that all ORs included in the Catalog are >1. Appropriate unit and increase/decrease are include...
along with the reported allele, so that all ORs included in the Catalog are >1. Appropriate unit and increase/decrease are included for beta coefficients.
Entrez Gene ID for nearest upstream gene to rs number, if not within gene (NCBI) DOWNSTREAM_GENE_ID: Entrez Gene ID for nearest downstream gene to rs number, if not within gene (NCBI) SNP_GENE_IDS: Entrez Gene ID, if rs number within gene; multiple genes denotes overlapping transcripts ...
cut -f 2,5 gwascatalog.txt |perl -alne '{$hash{$_}++}END{print "$_" foreach sort {$hash{$a} <=> $hash{$b}} keys %hash}' |cut -f 2 |perl -alne '{$hash{$_}++}END{print "$_\t$hash{$_}" foreach sort {$hash{$a} <=> $hash{$b}} keys %hash}' Hum Genet 4...
To explore the genetic overlap of epilepsy with other diseases, we first used the GWAS Catalog37 to cross-reference the 26 genome-wide epilepsy loci with other traits with significant associations (P < 5 × 10−8) for the same SNP, or SNPs in strong LD with our lead SNPs (as...
Network-assisted analysis provides a powerful approach to explore the joint effects of multiple genetic factors on disease and to discover new candidate genes that are missed by single-marker analysis. This is of particular interest for asthma where the number of loci reported by GWAS is relatively...
According to DisGeNet and the NHGRI-EBI GWAS Catalog, over 170 genes are reported to be associated with inflammatory bowel diseases. Despite the appreciable number of GWAS findings, only a few of these have shown immediate impact in clinical practice. This is not surprising. GWAS only offer one...
By searching the GWAS Catalog, some SNPs and mapped genes identified by ATPC are reported to be associated with lipid traits. Through further analysis for GWAS results, we also find some Gene Ontology terms and biological pathways related to lipids....
the AMP-AD project [52], there are no strong GWAS-based association signals reported in this region of chromosome 19 and relevant cognitive traits in the GWAS catalog (https://www.ebi.ac.uk/gwas/regions/chr19:48361628-48476971), except for an association with self-reported mathematical ...
The EBI GWAS catalog was used to determine the number of total GWASs reported from 2005 through the end of 2016, which are shown in blue. The number of post-GWAS functional studies reported each year were also identified (orange line) by (1) reviewing the titles, and in some cases, abs...