2024 EHA abstract PB2101: INTENSIVE THERAPY OF AGGRESSIVE B-CELL LYMPHOMAS WITH TP53 GENE MUTATION 声明 本资讯旨在帮助医疗卫生专业人士更好地了解相关疾病领域最新进展。本公众号对发布的资讯内容,并不代表同意其描述和观点,仅为提供更多信息。...
(1996) Frequent TP53 gene alterations (mutation, allelic loss, nuclear accumulation) in primary non-small cell lung cancer. Eur. J. Cancer 32A: pp. 335-341Shipman R,Schraml P,Colombi M et al.Frequent TP53 gene alterations (mutation, allelic loss, nuclear accumulation) in primary non-small ...
[9] Bowen D, Groves MJ, Burnett AK, et al. TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis. Leukemia. 2009. 23(1): 203-6. [10] Kulasekararaj AG, Smith AE, Mian SA, et al. TP53 mutations in m...
摘要 Pancreatic cancer is a malignant form of cancer with one of the worst prognoses. The poor prog nosis and resistance to therapeutic modalities have been linked to TP53 mutation. Pathological examinations, such as biopsies, cannot be frequently performed in clinical practice; therefore, noninvasive...
TP53的突变图谱包括超过2000种已知的错义突变,TP53是一种在大约一半的所有癌症中被突变的肿瘤抑制基因。 为了充分利用TP53突变状态进行个性化医疗,对这些突变的功能多样性进行全面理解是至关重要的。 我们使用饱和基因组编辑和CRISPR介导的同源定向修复进行了深度突变扫描,以在癌细胞中工程化9225种TP53变异。
Li YF, Zhao XF, Tian Y, Xiao XY, Yan CY, Shen H. Case Report: Pulmonary sarcomatoid carcinoma complicating TP53 mutation treated successfully with Tislelizumab combined with Anlotinib-a case report. Front Genet. 2022 Jul 22;13:949989. doi: 10.3389/fgene.2022.949989. PMID: 35938033; PMCID...
CONCLUSION: The TP53 germline mutation is more common in Chinese population with a high risk for breast cancer than previously thought. TP53 gene mutation screening should be considered particularly for patients with a family h...
(3) these mutations arise at selected sites in the gene due to a specific DNA sequence, such as a methylated cytosine residue in a CpG dinucleotide, which has a higher mutation rate changing C to T nucleotides, (4) along with the observed change in mutant p53 proteins, which produce a ...
Clinical characteristics and overall survival among acute myeloid leukemia (AML) patients with TP53 gene mutation (TP53m) or chromosome 17p deletion (17p del). Presented at 64th American Society of Hematology Annual Meeting and Exposition; December 10-13, 2022; New Orleans, LA. Abstract 603. ...
[关键词 ] 前列腺癌 ;TP53 基因 ;预后 ;基因检测 ;突变 DOI:10.13201/j.issn.1001-1420.2022.12.004 [中图分类号 ] R737.25 [文献标志码 ] A ClinicalfeaturesandprognosticvalueofTP53genemutation inpatientswithprostatecancer QIFeng LIXiao XU Weizhang CAI Hongzhou XU Ting YU Bin ZOU Qing XU Zicheng (...