TP53基因检测是指通过检测某个个体的TP53基因（也称为肿瘤基因p53）来评估患者对抗癌发作的风险。它是世...
There was a very good agreement between protein expression and the presence of TP53 mutation (P=0.0005). No significant correlation was found regarding age, gender, clinical stage and LDH level and TP53 mutations. Comparison of EFS curves using the log-rank test were also not significant. ...
Due to the frequent occurrence of TP53 as a concomitant mutation, relevant studies have explored the prognosis and drug resistance of TP53 and other genotype co mutations [24,25,26,27]. In this study, Wilcoxon rank sum test analysis showed a correlation between TP53 and nodule growth (P =...
Test code(s) 92560 Question 1. What is the clinical application of this test? Question 2. The gene mutation in this individual’s family is known. What other test might be appropriate? Question 3. What are the clinical indications for this testing? Question 4. Whom can I ask for help...
ConclusionGene test are recommended for children and their families with SHH subtype medulloblastoma and choroid plexus cancer to rule out germline TP53 mutation and to provide an individualized treatment plan for patients with LFS. Keywords:Pediatric brain tumor;Li-Fraumeni syndrome;Medulloblastoma;Choroid...
TP53is a tumor suppressor gene involved in multiple cellular processes that coordinate DNA damage response [1]. SomaticTP53pathogenic variants (PVs) occur in most tumor types, and when present in the germline, they cause an autosomal dominant cancer susceptibility condition called Li-Fraumeni syndrome...
ConclusionGene test are recommended for children and their families with SHH subtype medulloblastoma and choroid plexus cancer to rule out germline TP53 mutation and to provide an individualized treatment plan for patients with LFS...
(https://www.cbioportal.org/). The data were sequenced on Illumina platform. We retrieved the RSEM normalised counts forBCAR1gene along withTP53mutation status (wild type or mutant), survival months, and status (alive or dead). After filtering off samples with missing information, METABRIC ...
To test the notion thatRnf114bis a TP53 target gene, we examined the expression ofRnf114bin various cell types. We showed thatRnf144bexpression is induced in TP53-dependent fashion in TP53 wild type MEFs, A549, and 3KT cells in response to Nutlin-3a (Fig.2E). In addition,Rnf144bwas ...
geneTP53-LSC sAML signature. l, Kaplan–Meier analysis of AML patients (n = 322) from the BeatAML cohort stratified by p53-LSC signature score (high, above median; low, below median) derived ink(related to Extended Data Fig.6).Pindicates log-rank testPvalue and HR, hazard ratio. ...