TNF-aCrosstalkThe pro-inflammatory cytokine tumor necrosis factor-a (TNF-a) is a key regulator in immune responses, inflammation and programmed cell death (apoptosis). TNF-a exerts its biological activities through activation of multiple signaling effectors, including IKK, JNK and caspases. ...
Accordingly, the present results suggest that activation of TNF-a/TNFR1 signaling promotes gastric tumorigen- esis through induction of these tumor-promoting factors in tumor epithelial cells. TNF-a/TNFR1 signaling in gastric tumorigenesis H Oshima et al 3821 (Figure 1d). Therefore, it is ...
TNFα signaling blockade by a dominant-negative TRAF-2 delivered by adenoviral vector inhibits NF-κB and JNK activation and IL-8 expression in human intestinal epithelial cellsTNFα signaling blockade by a dominant-negative TRAF-2 delivered by adenoviral vector inhibits NF-κB and JNK activation an...
Laboratory Investigation (2010), 1–13 & 2010 USCAP, Inc All rights reserved 0023-6837/10 $32.00 RETRACTED Blockade of TNF-a signaling suppresses the AREG-mediated IL-6 and IL-8 cytokines secretion induced by anti-Ro/SSA autoantibodies Margherita Sisto1,4, Sabrina Lisi1,4, Dario Domenico ...
Thus, E1B 19K blocks TNF-α-mediated death signaling by inhibiting a specific form of Bax that interrupts caspase activation downstream of caspase-8 and upstream of caspase-9. 展开 关键词: Adenovirus E1B Proteins Apoptosis Carrier Proteins Proto-Oncogene Proteins 腺病毒E1B蛋白质类 脱噬作用 DOI: ...
Thus, TNF-␣ induced a 19K–Bax interaction in adenovirus-infected cells that may be the point of inhibi- tion of death signaling. TNF-␣ Induces a Conformational Change in Bax It was curious that Bax only interacted with E1B 19K when cells were treated with TNF-␣. Treating cells ...
To address the role of TNF-α during neutrophil migration, we examined its effect on the migration of neutrophils in the presence and absence of the inflammatory mediator interleukin-8 (IL-8) and examined the contribution of p38 MAPK signaling to this regulation. Our findings demonstrate that TNF...
Modulation of TNF-αpathways is a common theme in studies ofviral subversion of the host immune response (28), presumablybecauseTNF-αsignaling is so crucial to the antiviral response (29).Poxviruses are known to encode several homologs of theTNF-αreceptor (30). CrmB is the only TNF-recep...
The role of TNF-α in the signaling pathway of AGEP, SJS/TEN has theoretical support, but currently, the clinical efficacy of TNF-α inhibitors in the treatment of SCARs has only been reported in individual cases and case series in the literature, without large-scale clinical trials to confi...
TNF-R1Signaling:ABeautifulPathwayGuoqingChenandDavidV.Goeddel* Tumornecrosisfactor(TNF)isamajormediatorofapoptosisaswellasextracellularsignal-regulatedkinasekinasein,ammationandimmunity,andithasbeenimplicatedinthepathogenesiskinase1(MEKK1)orapoptosis-stimulatedofawidespectrumofhumandiseases,includingsepsis,diabetes(canc...