Furthermore, TNFa treatment enhances HESC induced trophoblast migration while inhibition of TNF receptor 1 (TNFR1) in stroma cells abolish the induction of trophoblast migration and invasion. B Conclusions: b We report for the first time a novel role for TNFa signaling in regulating the...
TNFAIP3-upregulated RIP3 exacerbates acute pancreatitis via activating NLRP3 inflammasome. Authors - Yifan Wang View Article human WB Mol Cell Biol LncRNA HOXA-AS3 integrates NF-κB signaling to regulate endothelium inflammation. Authors - Xinxing Zhu View ArticleSee more citationsProteintech...
24.Tracey D,Klareskog L,Sasso EH,Salfeld JG,Tak PP.肿瘤坏死因子拮抗剂作用机制:全面综述(Tumor necrosis factor antagonist mechanisms of action:a comprehensive review.)Pharmacol Ther.2(2008)244-79. 25.Wajant H,Pfizenmaier K,Scheurich P.肿瘤坏死因子信号传导(Tumor necrosis factor signaling).Cell ...
MYMD-1 is a drug platform based on a clinical stage small molecule that regulates the immune system to control TNF-alpha (TNF-α), which drives chronic inflammation, and other pro-inflammatory cell signaling cytokines. MYMD-1 is being developed to treat diseases and disorders marked by acute ...
16.De A, Dainichi T, Rathinam CV, Ghosh S. The deubiquitinase activity of A20 is dispensable for NF-kappaB signaling. EMBO Rep. 2014;15(7):775-83. 17.Lu TT, Onizawa M, Hammer GE, Turer EE, Yin Q, Damko E, et al. Dimerization and ubiquitin mediated recruitment of A20, a comple...
The gene TNFAIP3 acts as a negative regulator of the NF-κB signaling pathway. TNFAIP3 encodes the A20 protein,which exerts a potent anti-inflammatory effect and plays a pivotal role in the regulation of inflammation and immunity. In recent years,TNFAIP3 has garnered significant attention as a...
Overall, these results suggest thatsignaling can be enhanced by a second genetic alteration inand highlights a potential opportunity for therapeutic targeting.doi:10.1038/s41408-018-0130-3Wenzl, KerstinManske, Michelle K.Sarangi, VivekanandaAsmann, Yan W....
[3] Sarah L. Gaffen, IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases.Cell Signal.2013Dec;25(12):2335-47. doi: 10.1016/j.cellsig.2013.07.021. 今天的分享就到这里了哦,各位宝宝们要随时留意关注小编,在新的一年里百奥赛图会给大家带来不一样的惊喜和收获,期待...
The direct binding of rituximab to CD20 can trigger low-level apoptosis of tumor cells.6 Alterations in the apoptotic pathway signaling could therefore lead to cells becoming resistant to rituximab. Rituximab-resistant cell lines have been produced through repeated exposure to the antibody. These cell...
Further, we observed that nuclear factor-kappaB (NF-κB) signaling which mediates inflammatory response was significantly inhibited in CVB3-infected mice with Ad-A20 treatment. Finally, we revealed that A20 was required to inhibit CVB3-induced NF-κB signaling by restricting TNF receptor associated ...