Signaling pathway via TNF-a/NF-kB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis. Am J Physiol Gastrointest Liver Physiol 2009;296:G850-9.Onizawa M, Nagaishi T, Kanai T, Nagano K, Oshima S, Nemoto Y, et al. Signaling pathway via TNF-a/NF-...
TNFAIP2 promotes OSCC metastasis via activating NF-κB signaling. (A) Go enrichment analysis based on the CHIP-seq. (B, D, F) Wound healing (B), transwell (D) and tube formation experiment (F) after TNFAIP2 overexpression and blocked by NF-κB inhibitor BAY 11-7082 (2µM, 24 h)...
39, No. 1, 121-127, February 2007 TNF-α upregulates PTEN via NF-κB signaling pathways in human leukemic cells Young-Rae Lee1, Hong-Nu Yu1, Eun-Mi Noh1, Hyun Jo Youn1, Eun-Kyung Song2, Myung-Kwan Han2, Chang-Sik Park3, Byung-Soo Kim4, Young-Seok Park4, Byung-Kwon Park4,...
而黄连素能下调由其诱导的VEGF表达,可能是通过NF-~B信号通路所介导的。 关键词:黄连素;HepG2; 血管内皮细胞生长因子; 肿瘤坏死因子一a; 核转录因子一xB 中图分类号:R282.71 DOI:10.3870/j.issn.1672-0741.2014.04.004 EffectofBerberineonTNF-a·-inducedVEGFExpressionviaNF_。KBSignalingPathway ...
种植体周围炎/白细胞介素1β/肿瘤坏死因子α/RANKL/OPG/NF-κB受体活化因子配体; Key words Peri-implantitis/Interleukin-1β/Tumor necrosis factor-α/Receptor activator for nuclear factor-κB ligand;/Osteoprotegerin/Nuclear transcription factor kappaB signaling pathways ...
Tumor necrosis factor (TNF) is a pleiotropic cytokine that signals inflammation as well as cell death. We focus herein on the inflammatory pathway, giving particular emphasis to the in vitro methods used to study intracellular signaling mediators. The si
NF-kBp65能抑制糖皮质激素或cAMP诱导的PEPCK的转录[2]。而TNF-α通过激活核受 体辅抑制物HDAC3-SMRT募集至PEPCK基因启动子,进而抑制PEPCK基因的转录,且 TNF-α对PEPCK基因转录的抑制依赖于IKK/NF-kB通路的激活[3]。因此,我们假设,在 肝细胞中NF-kBp65参与调节核受体辅抑制物与PEPCK基因启动子间的相互作用。
if NF-κB activation is defective, c-FLIP expression will not surpass the threshold required to protect cells from TNF-induced apoptosis. TNFR1-mediated signal transduction therefore includes a checkpoint, resulting in cell death (via complex II) in instances where the initial signal (via complex ...
IFN-gamma and TNF-alpha synergistically induce mesenchymal stem cell impairment and tumorigenesis via NFkappaB signaling Wingless proteins, termed Wnt, are involved in embryonic development, blood cell differentiation, and tumorigenesis. In mammalian hematopoiesis, Wnt signal... L Wang,Y Zhao,Y Liu,....
www.nature.com/scientificreports OPEN Received: 19 June 2018 Accepted: 12 December 2018 Published: xx xx xxxx Ghrelin protects against contact dermatitis and psoriasiform skin inflammation by antagonizing TNF-α/NF-κB signaling pathways Ruize Qu1,2, Xiaomin Chen1,2, Jing Hu1,2,Yufeng...