[4]. Berguetti T, et al. TNF-α Modulates P-Glycoprotein Expression and Contributes to Cellular Proliferation via Extracellular Vesicles. Cells. 2019 May 24;8(5):500. [5]. Onizawa M, et al. Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved...
TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signaling and neurotoxicityNeuroimmunologymiRNAsGrowing evidences suggest that sustained neuroinflammation, caused by microglia overactivation, is implicated in the development and aggravation of several neurological and psychiatric disorders...
These results confirmed the presence of a functional NF-κB signaling pathway in both jejunum- and colon- derived organoids. Thus the lack of reporter activity in colon-derived organoids would not be associated with an alteration of this signaling pathway. In addition to TNF-α, the intestinal...
TNF-α can be activated by Pathogen-Associated Molecular Patterns (PAMPs) such as bacterial or viral DNA, flagellin, or lipopolysaccharide (LPS), through the NFkB pathway. PAMPs can be recognized by Toll-like receptors (TLRs) thereby initiating a kinase cascade which phosphorylates and degrades ...
Paeonol from Hippocampus kuda Bleeler suppressed the neuro-inflammatory responses in vitro via NF-κB and MAPK signaling pathways Inflammation has recently been implicated as a critical mechanism responsible for neurodegenerative diseases. In this study, paeonol (1-(2-hydroxy-4-methox... SWA Himaya...
IL-1β activates four signaling cascades upon binding to its cell surface receptor IL-1RI. The best characterized cascade involves NFkB (nuclear factor kB), the three other activate the terminal MAPKs (mitogen activated protein kinases) JNK ...
Interestingly, we found several signaling pathways specific to either the TNFi group or the IL-17Ai group. JAK and STAT are among the most highlighted pathways specific to the TNFi group. Identifying JAK/STAT pathway is interesting as JAK inhibitors are a major class of therapies that have ...
alleviated inflammation and apoptosis via the reduction of TNF-α levels. Insulin and glucagon-producing alpha and beta cells in the islets of Langerhans in CDDP-treated rat pancreatic tissue showed decreased immunopositivity. The decreased immunopositivity of alpha and beta cells can be explained in...
The present invention relates to variants of TRAF2 which demonstrate the ability to inhibit the TNF α signaling path-way. In particular, applicants have isolated a splice variant of
et al. “IL-12 receptor deficiency revisited: IL-23-mediated signaling is also impaired in human genetic IL-12 receptor b1deficiency” Eur. J. Immunol. (2003) vol. 33, pp. 3393-3397. International Preliminary Report on Patentability for PCT/US2011/058869 dated May 7, 2013. International...