Heat shock transcription factor 1 attenuates TNFa-induced cardiomyocyte death through suppression of NFkB pathwayGENE -AMSTERDAM-L.C.HuangM.JiangTangJ.
As TL1A-induced phosphorylation of nuclear factor-kB is part of the TL1A signaling pathway, we measured phosphorylation of nuclear factor-kB in CD4 þ T cells by intracellular phospho- flow cytometry.32 TL1A induced phospho-nuclear factor-kB in CD4 þ T cells within 10 min, which can ...
NF-κB signaling pathway3. Mutant, truncated A20 proteins are likely to act through haploinsufficiency because they do not exert a dominant-negative effect in overexpression experiments. Patient-derived cells show increased degradation of IκBα and nuclear translocation of the NF-κB p65 subunit ...
Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway. Pubmed:24962643 Archives of Oral Biology Hyperlipidemia causes changes in inflammatory responses to periodontal pathogen challenge: Impli...
Kaposi’s sarcoma-associated herpesvirus (KSHV) K13/vFLIP (viral Flice-inhibitory protein) induces transcription of numerous genes through NF-κB activation, including pro-inflammatory cytokines, which contribute to the pathogenesis of Kaposi’s sarcoma
Therefore, the aberrant signaling of the A20/NF-kB/SMAD pathway may be a cause of the pathogenesis of ITP. ATRAdoi:10.1182/blood.V128.22.364.364JiangQianJinZhangXiao-HuiYunJia-MinHaoLin-LinLan-PingBlood: The Journal of the American Society of Hematology...
PLCepsilon knockdown exhibits no effect on both the NF-kappaB-cis-element-mediated transcription per se and the post-translational modifications of NF-kappaB implicated in transcriptional regulation, suggesting that PLCepsilon constitutes a yet unknown signaling pathway distinct from the NF-kappaB pathway...
Polymorphisms in the inflamma- tory pathway genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG are associated with susceptibility of inflammatory bowel disease in a Danish cohort. PLoS One 2014;9:e98815....
(2001) Expression of ring (R)nger- deleted TRAF2 sensitizes metastatic melanoma cells to apoptosis via up-regulation of p38, TNFa and suppression of NF-kB activities. Oncogene, 20, 2243.Ivanov VN, Fodstad O, Ronai Z. Expression of ring finger-deleted TRAF2 sensitizes metastatic melanoma ...
Suppression of the aberrantly activated TNFA-NFKB pathway in the testicular niche of patients with nonobstructive azoospermia (NOA) restores spermatogonial stem cell self-renewal and expansiondoi:10.1016/j.fertnstert.2015.07.113Yango, P.L.University of California, San Francisco, San Francisco, CA;...