Therefore, the aberrant signaling of the A20/NF-kB/SMAD pathway may be a cause of the pathogenesis of ITP. ATRAdoi:10.1182/blood.V128.22.364.364JiangQianJinZhangXiao-HuiYunJia-MinHaoLin-LinLan-PingBlood: The Journal of the American Society of Hematology...
TNFAIP3-upregulated RIP3 exacerbates acute pancreatitis via activating NLRP3 inflammasome. Authors - Yifan Wang View Article human WB Mol Cell Biol LncRNA HOXA-AS3 integrates NF-κB signaling to regulate endothelium inflammation. Authors - Xinxing Zhu View Article See more citationsProteintech...
NF-κB signaling pathway3. Mutant, truncated A20 proteins are likely to act through haploinsufficiency because they do not exert a dominant-negative effect in overexpression experiments. Patient-derived cells show increased degradation of IκBα and nuclear translocation of the NF-κB p65 subunit ...
As TL1A-induced phosphorylation of nuclear factor-kB is part of the TL1A signaling pathway, we measured phosphorylation of nuclear factor-kB in CD4 þ T cells by intracellular phospho- flow cytometry.32 TL1A induced phospho-nuclear factor-kB in CD4 þ T cells within 10 min, which can ...
infiltration of Cd11b+ inflammatory cells in the liver tissue (Figure 3N), the mRNA expression levels of cytokines (Tnf, Il6, Ccl2 and Il10; Figure 3O) in the liver, and the phosphorylation of major components (IKKβ, p65, and IκBα) of the NF-κB signaling pathway (Figure S3D)....
Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway. Pubmed:24962643 Archives of Oral Biology Hyperlipidemia causes changes in inflammatory responses to periodontal pathogen challenge: Impli...
Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway. Pubmed:24962643 Archives of Oral Biology Hyperlipidemia causes changes in inflammatory responses to periodontal pathogen challenge: Impli...
Tumor necrosis factor (TNFα) is a cytokine involved in Ang II signaling and promotes the inflammatory response via NF-kB. We hypothesized that activation of AT2 prevents TNFα stimulation of intercellular adhesion molecule-1 (ICAM-1) expression in human coronary artery endothelial cells (HCREC) ...
Heat shock transcription factor 1 attenuates TNFa-induced cardiomyocyte death through suppression of NFkB pathwayWuL.HuC.HuangM.JiangLuTangJ.ingentaconnectGene Amsterdam
Transient transfection assays were performed to evaluate the functional consequences of A20 mutations on the NF-kB signaling pathway. The mutated A20 variants (rs2230926G and InsGG) were both less effective than the WT A20 in inhibiting NF-kB-dependent transactivation of the reporter gene in respo...