Human genetic studies have linked single-nucleotide polymorphisms of TNFAIP3 with susceptibility to multiple human diseases, including ITP. SMAD7 is another important factor that regulates megakaryocytic differentiation. All-trans retinoic acid (ATRA) could inhibit NF-kB signaling, and ATRA therapy could...
Haake SM, Dinh CT, Chen S, Eshraghi AA, and Van De Water TR. Dexamethasone protects auditory hair cells against TNFalpha-initiated apoptosis via activation of PI3K=Akt and NFkB signaling. Hear Res 255: 22-32, 2009.Haake, S.M., Dinh, C.T., Chen, S., Eshraghi, A.A., and VanDe...