This result suggests that USP4 is involved in the downregulation of TNFa-induced TAK1 polyubiquitination and recruitment of downstream signaling components. TAK1 mediates TNFa-induced NF-kB activation via IKK phosphorylation and activation.42 Therefore, we further ana- lyzed the effect of USP4 ...
Conclusion Thus, the results of the present study suggest that A20 regulates UCH-L1 expression via the NF-kappa B signaling pathway and A20 deficiency might play an important role in LN pathogenesis. Therefore, the A20 protein may serve as a promising therapeutic target for LN.Sun, LingZou, ...
In light of numerous mechanisms by which NF-kB suppression alters immune function, it has been the target of therapeutic trials. Several methods of pharmacologic inhibition of NF-kB activation and signaling are currently being examined in models of human disease, including muscular dystrophy13, ...
TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in...
Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway. Pubmed:24962643 Archives of Oral Biology Hyperlipidemia causes changes in inflammatory responses to periodontal pathogen challenge: Impli...
Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway. Pubmed:24962643 Archives of Oral Biology Hyperlipidemia causes changes in inflammatory responses to periodontal pathogen challenge: Impli...
A20 is a ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities, and involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Upon ...
背景介绍:Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors(TLRs) through terminating NF-kappa-B activity. Essential compo...
NF-kB at a point distal to activation of the IKK complex in PDA cells, whereas a role of GSK-3b in maintaining constitutive NF-kB signaling via IKK was also reported.25,28 Here we provide evidence that GSK- 3b is basically dispensable during TNFa-induced canonical NF-kB activation up to...
ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks. Cell Cycle 2011; 10: 481–491. 46. Ahmed KM, Nantajit D, Fan M, Murley JS, Grdina DJ, Li JJ. Coactivation of ATM/ERK/NF- kappaB in the low-dose radiation-induced radioadaptive response in human skin ...