TNF signaling pathwayProstate cancer is one of the most lethal malignancies, and androgen deprivation therapy remains the mainstay of treatment for prostate cancer patients. Although androgen deprivation can initially come to remission, the disease often develops into castration-resistant prostate cancer (...
USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway. Authors - Lei Zhang View Article human,mouse WB,IHC Am J Cancer Res ZY-444 inhibits the growth and metastasis of prostate cancer by targeting TNFAIP3 through TNF signaling pathw...
The gene TNFAIP3 acts as a negative regulator of the NF-κB signaling pathway. TNFAIP3 encodes the A20 protein,which exerts a potent anti-inflammatory effect and plays a pivotal role in the regulation of inflammation and immunity. In recent years,TNFAIP3 has garnered significant attention as a...
As TL1A-induced phosphorylation of nuclear factor-kB is part of the TL1A signaling pathway, we measured phosphorylation of nuclear factor-kB in CD4 þ T cells by intracellular phospho- flow cytometry.32 TL1A induced phospho-nuclear factor-kB in CD4 þ T cells within 10 min, which can ...
Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway. Pubmed:24962643 Archives of Oral Biology Hyperlipidemia causes changes in inflammatory responses to periodontal pathogen challenge: Impli...
which is typically considered a polygenic disorder with onset in early adulthood2. A20 is a potent inhibitor of the NF-κB signaling pathway3. Mutant, truncated A20 proteins are likely to act through haploinsufficiency because they do not exert a dominant-negative effect in overexpression experiments...
Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway. Pubmed:24962643 Archives of Oral Biology Hyperlipidemia causes changes in inflammatory responses to periodontal pathogen challenge: Impli...
The direct binding of rituximab to CD20 can trigger low-level apoptosis of tumor cells.6 Alterations in the apoptotic pathway signaling could therefore lead to cells becoming resistant to rituximab. Rituximab-resistant cell lines have been produced through repeated exposure to the antibody. These cell...
infiltration of Cd11b+ inflammatory cells in the liver tissue (Figure 3N), the mRNA expression levels of cytokines (Tnf, Il6, Ccl2 and Il10; Figure 3O) in the liver, and the phosphorylation of major components (IKKβ, p65, and IκBα) of the NF-κB signaling pathway (Figure S3D)....
These observations support our contention that increased TNFa signalling in PAH causes an imbalance of BMP and NOTCH signalling that can be redressed through therapeutic targeting of the TNFa pathway. Discussion The mechanisms by which loss-of-function BMPR2 mutations underlie severe PAH with low ...