TNF-alpha Antagonists (2) TNF-alpha Agonists (3) TNF-alpha Modulators (4) New TNF-alpha Products Catalog No.Product NameInformationProduct Use CitationsProduct Validations S8037Necrostatin-1Necrostatin-1 (Nec-1) is a specificRIP1 (RIPK1)inhibitor and inhibits TNF-α-induced necroptosis withEC50...
TNF signaling pathway TNF alpha pathway TNF alpha, a pro-inflammatory cytokine, is produced by many cell types, including macrophages, lymphocytes, fibroblasts, and keratinocytes, in response to inflammation, infection, and other environmental stresses. TNF al...
TNF signaling pathway TNF alpha pathway TNF alpha, a pro-inflammatory cytokine, is produced by many cell types, including macrophages, lymphocytes, fibroblasts, and keratinocytes, in response to inflammation, infection, and other environmental stresses. TNF a...
Cellular biology The role of RIP ubiquitination in the TNFalpha signaling pathway STATE UNIVERSITY OF NEW YORK AT BUFFALO Xin Lin LiHongxiuStimulation of cells by TNFα triggers recruitment of various signaling molecules, including RIP, to the TNFα receptor 1 complex, which leads to activation ...
痛风急性发作过程中有多种炎性细胞、炎性因子参与,其中IL-1在炎症激活和维持中发挥了核心作用。除此之外TNF-α、IL-6等也参与了痛风急性发作的炎症过程,因此抑制或阻断TNF-α、IL-6将成为痛风治疗的新靶点。本文就TNFα对痛风(痛风性...
体外:TNF alpha (小鼠) (0, 2.5, 5, 10, 20, 40 ng/ml; 5 min) 以剂量依赖性方式刺激 NF-κB 通路并上调 CT26 细胞中 p65 和 IκBα 的磷酸化水平 [3].TNF alpha (小鼠) (1, 10 ng/mL; 7 days) 通过 TNFR1 激活诱导 SVZ 细胞的神经元分化[4]。TNF alpha (小鼠) (1, 10; 100 ng/...
TNFR1 Signaling Pathway TNFR1 (a.k.a. p55, CD120a) is the receptor for TNF(alpha) and also will bind TNF(beta). Upon binding TNF(alpha) a TNFR1+ cell is triggered to undergo apoptosis. This critical regulatory process is accomplished by activating the proteolytic caspase cascade that ...
The inflammatory cytokine Tumor Necrosis Factor Alpha (TNF-α) is known to trigger invasive growth, a physiological property for tissue healing, turning into a hallmark of progression in cancer. However, the invasive response to TNF-α relies on poorly understood molecular mechanisms. We thus invest...
The “cellular response to FGF signaling stimulus” category includes ZFP36 (Zinc finger protein 36), EGR3 (Early growth response 3), SNCA (Synuclein Alpha) and CXCL8. ZFP36 regulates mRNA stability of many important cytokines24 and sensitizes transformed cells lines to cell death25. EGR3 ...
The present invention relates to variants of TRAF2 which demonstrate the ability to inhibit the TNF α signaling path-way. In particular, applicants have isolated a splice variant of