http://16.DeA, Dainichi T, Rathinam CV, Ghosh S. The deubiquitinase activity of A20 is dispensable for NF-kappaB signaling. EMBO Rep. 2014;15(7):775-83. 17.Lu TT, Onizawa M, Hammer GE, Turer EE, Yin Q, Damko E, et al. Dimerization and ubiquitin mediated recruitment of A20, a...
Therefore, the aberrant signaling of the A20/NF-kB/SMAD pathway may be a cause of the pathogenesis of ITP. ATRAdoi:10.1182/blood.V128.22.364.364JiangQianJinZhangXiao-HuiYunJia-MinHaoLin-LinLan-PingBlood: The Journal of the American Society of Hematology...
NF-κB signaling pathway3. Mutant, truncated A20 proteins are likely to act through haploinsufficiency because they do not exert a dominant-negative effect in overexpression experiments. Patient-derived cells show increased degradation of IκBα and nuclear translocation of the NF-κB p65 subunit ...
Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway. Pubmed:24962643 Archives of Oral Biology Hyperlipidemia causes changes in inflammatory responses to periodontal pathogen challenge: Impli...
As TL1A-induced phosphorylation of nuclear factor-kB is part of the TL1A signaling pathway, we measured phosphorylation of nuclear factor-kB in CD4 þ T cells by intracellular phospho- flow cytometry.32 TL1A induced phospho-nuclear factor-kB in CD4 þ T cells within 10 min, which can ...
Kaposi’s sarcoma-associated herpesvirus (KSHV) K13/vFLIP (viral Flice-inhibitory protein) induces transcription of numerous genes through NF-κB activation, including pro-inflammatory cytokines, which contribute to the pathogenesis of Kaposi’s sarcoma
Signaling pathways for TNFa-induced COX-2 expression: mediation through MAP kinases and NFkB, and inhibition by certain nonsteroidal anti-inflammatory drugs. Adv Exp Med Biol 2002;507:503 - 508.Paik, J.; Lee, J. Y.; Hwang, D. Signaling pathways for TNFR- induced COX-2 expression: ...
Amphiphilic pyridinium salts block TNF alpha/NF kappa B signaling and constitutive hypersecre- tion of interleukin-8 (IL-8) from cystic fibrosis lung epithelial cells. Biochem Pharmacol 70: 381-393, 2005.S. Tchilibon, J. Zhang, Q. Yang, O. Eidelman, H. Kim, H. Caohuy, K.A. ...
TNFa suppresses link protein and type II collagen expression in chondrocytes: role of MEK1/2 and NFkB signaling pathways. J. Cell. Physiol. 197, 356-369.Seguin CA, Bernier SM: TNFalpha suppresses link protein and type II collagen expression in chondrocytes: role ...
Upon the TNFa trimers binding, TNF receptors also form trimers, undergo a conformational change, and enable the adaptor protein TRADD to bind to the death domain, and thus initiates the signal pathways such as the NF-kB, Jak/STAT, and the MAPK pathways, as well as the death signaling. ...