Mesenchymal stem cells derived from bone marrow have recently been described to localize to breast carcinomas and to integrate into the tumor-associated stroma. In the present study, we investigated whether adipose tissue-derived stem cells (ASCs) could play a role in tumor growth and invasion. ...
The gastrointestinal tract serves as a fast-renewing model for unraveling the multifaceted molecular mechanisms underlying remarkably rapid cell renewal, which is exclusively fueled by a small number of long-lived stem cells and their progeny. Stem cell activity is the best-characterized aspect of muco...
Brandau S, Jakob M, Hemeda H, Bruderek K, Janeschik S et al (2010) Tissue-resident mesenchymal stem cells attract peripheral blood neutrophils and enhance their inflammatory activity in response to microbial challenge. J Leukoc Biol 88(5):1005- 1015. doi:10.1189/jlb.0410207...
Tissue resident mesenchymal stem cells (MSCs) are known to participate in tissue regeneration that follows cell turnover, apoptosis, or necrosis. It has been long known that aging impedes an organism's repair/regeneration capabilities. In order to study the age associated changes, the molecular cha...
Tissue-resident memory CD8+ T cells (TRM cells) are crucial in protecting against reinvading pathogens, but the impact of reinfection on their tissue confinement and contribution to recall responses is unclear. We developed a unique lineage tracer mouse
Tissue-resident macrophages self-renew locally, independent of adult haematopoiesis3,4,5, whereas short-lived monocyte-derived macrophages arise from adult haematopoietic stem cells, and accumulate mostly in inflamed lesions1. How these macrophage lineages contribute to the TME and cancer progression ...
First described on the basis of their inherent capacity to directly kill tumor cells without prior sensitization, NK cells are now known to participate in a wide variety of immune responses, such as viral infections, stem cell transplantation, and pregnancy. In addition, they can respond to pro...
Effects of transplanted bone-marrow-derived mesenchymal stem cells in animal models of acute hepatitis Our aim was to evaluate the therapeutic effects of bone-marrow-derived mesenchymal stem cells (BMMSCs) on ConA-induced hepatitis and to elucidate the possi... X Zhu,B He,X Zhou,... - 《C...
Thus, hematopoietic stem cell-independent embryonic precursors transiently present in the YS and the FL give rise to long-lasting self-renewing macrophage populations. 展开 关键词:macrophages monocytes fetal liver yolk sac C-Myb erythro-myeloid progenitors hematopoiesis hematopoietic stem cells ...
Ongoing Production of Tissue-Resident Macrophages from Hematopoietic Stem Cells in Healthy Adult Macaques Macrophages are essential for homeostatic maintenance of the anti-inflammatory and tolerogenic intestinal environment, yet monocyte-derived macrophages can... Chuanfeng Wu MD PhD *,Andrew R. Rahmberg ...