Tissue-resident memory (TRM) T cells are distinct population of non-circulating lymphocytes that play an important role in mediating regional immunity. TRM- like cells have now been identified as a component of tumor-infiltrating lymphocytes in several human tumors and correlate with outcome and ...
Tissue-resident memory CD8+ T cells (TRM cells) are crucial in protecting against reinvading pathogens, but the impact of reinfection on their tissue confinement and contribution to recall responses is unclear. We developed a unique lineage tracer mouse
Tissue-resident memory T cells (TRM cells) provide protective immunity, but the contributions of specific tissue environments to TRM cell differentiation and homeostasis are not well understood. In the present study, the diversity of gene expression and
tissue-residentmemoryTTissue-resident memory T (TRM ) cells are CD8+ T lymphocytes that reside in the tissues, including tumours. This T cell subset possesses a magnitude of cytotoxicity, but their epigenetic regulation has not been studied. Here, we investigate the impact of perforin DNA ...
tissue resident memory TcellsFollowing infection, tissue resident memory T cells (Trm) are thought to be left behind at sites of antigen encounter to protect affected tissues against subsequent reinfection. In this issue of the European Journal of Immunology, however, Pascutti etal. [Eur. J. ...
Tissue-resident CD4+and CD8+T cells have been identified in many tissues and organs of mice and humans. These cells are defined as those that undergo little or no recirculation. Tissue residency is not just a feature of subsets of memory αβ T cells. Other populations of immune cells, inc...
ni.2019-Hobit- and Blimp-1-driven CD4+ tissue-resident memory T cells control chronic intestinal inflammation 热度: [2009][Nature][Kragl M]Cells keep a memory of their tissue origin during axolotl limb regeneration 热度: effector memory regulatory t cells were most effective at suppressing rankl...
Tissue-resident memory T (Trm) cells constitute a recently identified lymphocyte lineage that occupies tissues without recirculating. They provide a first response against infections reencountered at body surfaces, where they accelerate pathogen clearance. Because Trm cells are not present within peripheral...
Tissue-resident memory T cells 作者:Shin Haina; Iwasaki Akiko* 来源:Immunological Reviews, 2013, 255(1): 165-181. DOI:10.1111/imr.12087 T cells cell lineages and subsets infectious diseases T-cell migration vaccines 摘要 Tissues such as the genital tract, skin, and lung act as barriers agai...
Tissue residency is not just a feature of subsets of memory αβ T cells. Other populations of immune cells, including regulatory T cells, natural killer T (NKT) cells, NK cells, γδ T cells and innate lymphoid cells have been defined as being permanently resident in tissues. ...