Tissue resident memoryTumor immunityTumor infiltrating lymphocytesTissue-resident memory (TRM) T cells are distinct population of non-circulating lymphocytes that play an important role in mediating regional immunity. TRM- like cells have now been identified as a component of tumor-infiltrating lymphocytes...
Tissue-resident memory CD8+ T cells (TRM cells) are crucial in protecting against reinvading pathogens, but the impact of reinfection on their tissue confinement and contribution to recall responses is unclear. We developed a unique lineage tracer mouse
To quantitatively and systematically capture the spatial distribution of antigen-specific CD8 T cells in the SI responding to lymphocytic choriomeningitis virus (LCMV) infection, we used T cell receptor transgenic CD8 T cells (P14 CD8 T cells), which specifically recognize the LCMV glycoprotein 33–4...
Tissue-resident memory T cells (TRM cells) provide protective immunity, but the contributions of specific tissue environments to TRM cell differentiation and homeostasis are not well understood. In the present study, the diversity of gene expression and
Tissue-resident memory T (TRM) cells are a newly described subset of memory T cells. The best characterized TRM cells are CD8+ and express CD103 and CD69.
originate in epithelial layers, the nature and spatiotemporal dynamics of immune responses that maintain cancer–immune equilibrium in these tissue compartments remain unclear. Here, using a mouse model of transplantable cutaneous melanoma 5 , we show that tissue-resident memory CD8 + T cells (T RM...
Identified about a decade ago, tissue-resident memory T cells (TRM) provide antigen-specific protection from pathogens and viruses in peripheral tissues. Characterized by their residency in tissues and distinct inability to...
Tissue-resident memory T (Trm) cells constitute a recently identified lymphocyte lineage that occupies tissues without recirculating. They provide a first response against infections reencountered at body surfaces, where they accelerate pathogen clearance. Because Trm cells are not present within peripheral...
These tissue-resident memory T cells (abbreviated Trm cells to distinguish them from Tcm and Tem cells) derived from precursors that entered tissues during the effector phase of immune responses and remained positioned within this compartment. The identification of this memory T cell lineage ...
Memory T cells are fundamental to maintain immune surveillance of the human body. During the past decade, it has become apparent that non-recirculating resident memory T cells (TRMs) form a first line memory response in tissues to tackle re-infections. The fact that TRMs are essential for loca...