To quantitatively and systematically capture the spatial distribution of antigen-specific CD8 T cells in the SI responding to lymphocytic choriomeningitis virus (LCMV) infection, we used T cell receptor transgenic CD8 T cells (P14 CD8 T cells), which specifically recognize the LCMV glycoprotein 33–4...
tissue-resident memory T cellstranscription factorstransforming growth factor βCD8+ tissue-resident memory T (TRM) cells play crucial roles in defense against infections and cancer and have been implicated in autoimmune diseases such as psoriasis. In mice and humans, they exist in all nonlymphoid ...
CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against pathogens and malignancies, and the molecular processes that lead to TRM cell formation are therefore of substantial biomedical interest. Prior work has demonstrated that signals present in the inflamed tissue mic...
Tissue-resident memory CD8+ T cells (TRM cells) are crucial in protecting against reinvading pathogens, but the impact of reinfection on their tissue confinement and contribution to recall responses is unclear. We developed a unique lineage tracer mouse
In chronic inflammatory diseases of the central nervous system (CNS), immune cells persisting behind the blood-brain barrier are supposed to promulgate local tissue destruction. The drivers of such compartmentalized inflammation remain unclear, but tissue-resident memory T cells (TRM) represent a ...
| 人体免疫系统就像一支由专业士兵(免疫细胞)组成的军队,每个免疫细胞在抵抗疾病的过程中都发挥着独特的作用。近日,最新发表在《自然》(Nature)的一项研究中,科学家揭示了一种叫作组织驻留记忆CD8 T细胞(tissue resident memory CD8 T cells)的免疫细胞,根据其在小肠内的位置发挥独特的作用。 #免疫细胞 #细胞 #《...
originate in epithelial layers, the nature and spatiotemporal dynamics of immune responses that maintain cancer–immune equilibrium in these tissue compartments remain unclear. Here, using a mouse model of transplantable cutaneous melanoma 5 , we show that tissue-resident memory CD8 + T cells (T RM...
Tissue-resident memory T (Trm) cells constitute a recently identified lymphocyte lineage that occupies tissues without recirculating. They provide a first response against infections reencountered at body surfaces, where they accelerate pathogen clearance. Because Trm cells are not present within peripheral...
Thus, it is imperative to define how T-cell differentiation states can vary between the periphery and the tumor site, where the microenvironment impacts both functionality and longevity of T cells. A large subset of CD8+ T lymphocytes infiltrating the tumor site is represented by tissue-resident ...
Tissue-resident memory T (TRM) cells, functionally distinct from circulating memory T cells, have a critical role in protective immunity in tissues, are more efficacious when elicited after vaccination and yield more effective antitumor immunity, yet the signals that direct development of TRMcells are...