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急性感染中,CD8+初始T细胞在接受抗原刺激之后,可分化为CD8+效应T细胞(effector CD8+ T cells, TEFF)。如果抗原被清除,一部分的TEFF会持续存在,形成长寿的可以自我更新的记忆T细胞(memory CD8+ T cells,TMEM),以对再次感染产生快速的免疫反应。相反,在慢性感染或者肿瘤中,抗原持续存在,初始T细胞的分化将会变得不一样...
Jergović M, Coplen CP, Uhrlaub JL, Besselsen DG, Cheng S, Smithey MJ, Nikolich-Žugich J. Infection induced type I interferons critically modulate the homeostasis and function of CD8+ naïve T cells. Nat Commun 2021;12:5303. Michael St Paul , Pamela S Ohashi.The Roles of CD8+ T...
作者采用了LAF-1缺失的 cytotoxic T cells (CTLs) and LFA-1-/- Jurkat T cells。首先重复分析了代谢谱。实验证明LAF-1是Mg2+发挥糖酵解作用的中介。在野生型OY-1的CTL中,缺乏外源性的Mg2+导致Ca2+内流减弱。在LFA-1-/- Jurkat T cells也观察到了类似的现象。作为早期免疫突触启动信号的标志,作者进一步...
2. D. L. Barber, E. J. Wherry, D. Masopust, B. Zhu, J. P. Allison, A. H. Sharpe, G. J. Freeman, R. Ahmed, Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439, 682–687 (2006).3. M. F. Krummel, J. P. Allison, CTLA-4 engagement ...
host-extrinsic reprogramming of CD8+ T cells, contrasting with the intrahost gut microbiota-derived short-chain fatty acids. Therefore, TVA has potential translational applications for tumor treatment. 本论文研究了饮食来源的...
调节T细胞(regulatory T cells, Treg)是CD4 T细胞中一个特殊的亚群,其特异性的表达转录因子FOXP3。调节T 细胞的一个主要功能在于抑制来自其他免疫细胞过度的免疫反应【1】。近年来,越来越多的证据表明Treg是一个包括多个亚群的细胞类型,每个亚群都具有不同的转录因子表达,使得其获得类似于其他 CD4 T细胞亚群的特性,...
Watson MJ et al. Metabolic support of tumour-infiltrating regulatory T cells by lactic acid. Nature. 2021 Mar;591(7851):645-651. Wang H et al. CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors. Nat Immunol. 2020 Mar;21(3):298-308....
(mTOR) for homeostatic DC function. Specific ablation of Tsc1 in the DC compartment (Tsc1DC-KO) largely preserved DC development but led to pronounced reduction in nave and memory–phenotype cluster of differentiation (CD)8+ T cells, a defect fully rescued by concomitant ablation of mTor or ...