The function and dysfunction of memory CD8+ T cells in tumor immunity. Immunol. Rev. 283:194-212. https://doi.org/10.1111/ imr.12657Reading JL, Galvez-Cancino F, Swanton C, Lladser A, Peggs KS, Quezada SA. The function and dysfunction of memory CD8+ T cells...
Functional impairment of antigen-specific T cells is a defining characteristic of many chronic infections, but the underlying mechanisms of T-cell dysfunction are not well understood. To address this question, we analysed genes expressed in functionally impaired virus-specific CD8 T cells present in m...
The molecular details of immunoregulatory phenomena associated with CD8+ T lymphocytes have not been clearly elucidated. We tested the hypothesis that the cell surface glycoprotein CD8 is itself essential in mediating the inhibitory effects associated with CD8+ T cells. For this purpose we utilized a...
- 《Immunity》 被引量: 215发表: 2009年 Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism This is due to the increase in the plasma membrane cholesterol level of CD8(+) T cells, which causes enhanced T-cell receptor clustering and signalling as well as...
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In radioresistant tumor-bearing mice, the proportion of CD8+ T cells and IFN-γ production within immune cells decreased. Immunohistochemical analysis of human and animal tissue specimens resistant to radiotherapy showed a significant increase in the expression levels of PITPNC1, FASN, and CD155. ...
The generation of effector CD8+ T cells with lytic capacity is crucial for tumor control. Dendritic cells (DCs) provide important signals to promote naive CD8+ T cell priming and activation of effector T cells. Here, we report that the Notch pathway has an important role in both these proces...
exclusion of CD8 T cells in solid tumors38. These studies indicate unknown function of VCAM1 in controlling tumor immunity. Here, our study establishes the importance of motile regulation of iNKT cells in tumors. Macrophages and VCAM1 molecule in tumors respectively inhibit tumor infiltration and ...
结论 CHB患者外周血抗原特异性CD8+T细胞存在明显的功能缺陷,可能因病毒抗原持续刺激造成功能耗竭,但外周血出现抗原特异性CD8+T细胞仍表明患者体内出现较强抗病毒免疫反应。关键词:T细胞耗竭;慢性乙型肝炎;四聚体技术 PrimaryanalysisonthefunctionofperipheralbloodHBV specificCD8+TcellsfrompatientswithchronichepatitisB CAI...
PD-1 and Tim-3 Pathways Regulate CD8+ T Cells Function in Atherosclerosis. T cell-mediated immunity plays a significant role in the development of atherosclerosis (AS). There is increasing evidence that CD8+ T cells are also invol... Ming-Ke,Qiu,Song-Cun,... - 《Plos One》 被引量: ...