Secondary replicative function of CD8+ T cells that had developed an effector phenotype. Science. 2009; 323 :505–509.Bannard O, Kraman M, Fearon DT. Secondary replicative function of CD8+ T cells that had developed an effector phenotype. Science (New York, NY) 2009; 323 :505–509....
The generation of effector CD8+ T cells with lytic capacity is crucial for tumor control. Dendritic cells (DCs) provide important signals to promote naive CD8+ T cell priming and activation of effector T cells. Here, we report that the Notch pathway has an important role in both these proces...
CD8+ T-cells: function and response to HIV infection. Curr HIV Res 2004;2(1):23-37.N. Gulzar and K. F. T. Copeland, "CD8+ T-cells: function and response to HIV infection," Current HIV Research, vol. 2, no. 1, pp. 23-37, 2004....
Cells, C D TWang, TaoDai, HehuaWan, NiMoore, YolondaDai, ZhenhuaWang T, Dai H, Wan N, Moore Y, Dai Z. The role for monocyte che- moattractant protein-1 in the generation and function of memory CD8+ T cells. J Immunol 2008;180:2886-93.Wang T,Dai H,Wan N, et al.The role ...
CD8(+) T-cell effector function and transcriptional regulation during HIV pathogenesis. Immunol Rev 2013; 254:190-206.Demers KR;Reuter MA; Betts MR.CD8... KR Demers,MA Reuter,MR Betts - 《Immunological Reviews》 被引量: 85发表: 2013年 Enhanced effector function of CD8(+) T cells from he...
The primary immune response to Epstein Barr virus (EBV) is characterized by striking proliferation of EBV-specific CD8(+) T cells. In this study we have investigated the clonal composition and functional properties of the cells mediating this primary response and have analyzed the mechanisms that ...
结论 CHB患者外周血抗原特异性CD8+T细胞存在明显的功能缺陷,可能因病毒抗原持续刺激造成功能耗竭,但外周血出现抗原特异性CD8+T细胞仍表明患者体内出现较强抗病毒免疫反应。关键词:T细胞耗竭;慢性乙型肝炎;四聚体技术 PrimaryanalysisonthefunctionofperipheralbloodHBV specificCD8+TcellsfrompatientswithchronichepatitisB CAI...
(also known as B7-H1), enhanced T-cell responses. Notably, we found that even in persistently infected mice that were lacking CD4 T-cell help, blockade of the PD-1/PD-L1 inhibitory pathway had a beneficial effect on the ‘helpless’ CD8 T cells, restoring their ability to undergo ...
CD8 T cellscontinuous exposureimmunotoxicityT-cell functionsCellular and Molecular Immunology aims to report the dynamic progress being made in China and abroad in immunological research, and welcomes high-quality Research Articles, Reviews and Brief Reports across a broad range of topics including, but...
In radioresistant tumor-bearing mice, the proportion of CD8+T cells and IFN-γ production within immune cells decreased. Immunohistochemical analysis of human and animal tissue specimens resistant to radiotherapy showed a significant increase in the expression levels of PITPNC1, FASN, and CD155. ...