In a lethal mouse model of EBOV infection, we show that there is an increase in expression of the activation/maturation marker CD44 in CD4(+) and CD8(+) T cells late in infection, preceding a dramatic rebound of lymphocyte numbers in the blood. Furthermore, we observed both lymphoblasts ...
Cytotoxic CD8T cells recognize and eliminate infected or malignant cells that present peptide epitopes derived from intracellularly processed antigens on their surface. However, comprehensive profiling of specific major histocompatibility complex (MHC)-bound peptide epitopes that are naturally processed and ...
Finally, next-generation RNA sequencing revealed complex and unique transcriptional regulation of sorted effector pulmonary CD8+CD44+T cells from obese mice compared to lean mice following influenza infection. Collectively, the data suggest diet-induced obesity increases influenza virus pathogenesis, in ...
negative men, focusing primarily on IL-17-producing CD4 and CD8 T cells due to their importance in establishing and maintaining mucosal defenses, and examined associations between the frequencies of Th17 and Tc17 cell subsets and the availability of highly HIV-susceptible target cells in the RM. ...
These CD8+ T cells were interferon-γ (IFN-γ)–producing, antigen-experienced, central memory, and effector memory T cells. The major difference in antigen-specific T cells between healthy donors and patients was in their frequency, which was lowest in healthy donors, higher in patients, and...
Methods Lysosome-mediated degradation pathways were analyzed by flow cytometry in virus-specific CD8 T cells from chronic HBV patients, in comparison to patients able to resolve spontaneously HBV infection and healthy subjects. Mitochondrial function, intracellular proteostasis and cytokine production were ...
Immunodominance and functional alterations of tumor‐associated antigen‐specific CD8 T‐cell responses in hepatocellular carcinoma.pdf 2015-12-12上传 Immunodominance and functional alterations of tumor‐associated antigen‐specific CD8 T‐cell responses in hepatocellular carcinoma ...
IL-17-secreting CD8 T cells (Tc17) have been described in several settings, but little is known regarding their functional characteristics. While Tc1 cells produced IFN-gamma and efficiently killed targets, Tc17 cells lacked lytic function in vitro. Interestingly, the small numbers of IFN-gamma...
and Herrmann, T. (2000), Expression of functional CD8α β heterodimer on rat γ δ T cells does not correlate with the CDR3 length of the TCRδ chain predicted for MHC class I-restricted antigen recognition. Eur. J. Immunol., 30: 3562–3568. doi: 10.1002/1521-4141(200012)30...
In accord with the greatly reduced number of CD8+ T cells, spleen cells from KbDb-/- mice do not generate cytotoxic responses in primary mixed-lymphocyte cultures against MHC-disparate (allogeneic) cells. However, in vivo priming of KbDb-/- mice with allogeneic cells resulted in strong CD8+ ...