EM Verdegaal,C Hoogstraten,MH Sandel,PJ Kuppen,AA Brink,FH Claas,MC Gorsira,JF Graadt van Roggen,S Osanto.Functional CD8+ T cells infiltrate into nonsmall cell lung carcinoma. Cancer Immunology Immunotherapy . 2007Functional CD8 + T cells infiltrate into nonsmall cell lung carcinoma[J] . ...
Cytotoxic CD8T cells recognize and eliminate infected or malignant cells that present peptide epitopes derived from intracellularly processed antigens on their surface. However, comprehensive profiling of specific major histocompatibility complex (MHC)-bound peptide epitopes that are naturally processed and ...
Finally, next-generation RNA sequencing revealed complex and unique transcriptional regulation of sorted effector pulmonary CD8+CD44+T cells from obese mice compared to lean mice following influenza infection. Collectively, the data suggest diet-induced obesity increases influenza virus pathogenesis, in ...
深入研究「Tc17 CD8 T cells: Functional plasticity and subset diversity」主題。共同形成了獨特的指紋。 Cytotoxic T-Cell Immunology and Microbiology 100% Interleukin 17 Immunology and Microbiology 100% Cell Surface Immunology and Microbiology 25% CD4 Immunology and Microbiology 25% STAT3 Immu...
Methods Lysosome-mediated degradation pathways were analyzed by flow cytometry in virus-specific CD8 T cells from chronic HBV patients, in comparison to patients able to resolve spontaneously HBV infection and healthy subjects. Mitochondrial function, intracellular proteostasis and cytokine production were ...
IL-17-secreting CD8 T cells (Tc17) have been described in several settings, but little is known regarding their functional characteristics. While Tc1 cells produced IFN-γ and efficiently killed targets, Tc17 cells lacked lytic function in vitro. Interestingly, the small numbers of IFN-γ-posit...
Effective Elicitation of Human Effector CD8+ T Cells in HLA- B*51:01 Transgenic Humanized Mice after Infection with HIV-1. Humanized mice are expected to be useful as small animal models for in vivo studies on the pathogenesis of infectious diseases. However, it is well known t... Sato,Yo...
T cells expressionBackgroundThe changes in T cell subsets and programmed death ligand 1 (PD-L1) expression during the transition from ductal carcinoma in situ (DCIS) to early invasive breast cancer had not been well studied.doi:10.1016/j.clbc.2019.04.001Lv, Shuzhen...
TCF-1 and LEF-1 act upstream of Th-POK to promote CD4 T cell lineage choice and cooperate with Runx3 to silence the Cd4 gene in CD8 T cells 热度: CD8 T Cells Primed in the Periphery Provide Time-Bound Immune-Surveillance to the Central Nervous System(外周CD8T细胞对中枢神经系统的时间...
CD8+T cells in human hepatitis C virus (HCV) infection before and after treatment. After viral cure, phenotypic changes in clonally stable exhausted T cell populations suggested differentiation toward a memory-like profile. However, functionally, the cells showed little improvement, and critical ...