The gradual accumulation of genetic mutations in human adult stem cells (ASCs) during life is associated with various age-related diseases, including cancer1,2. Extreme variation in cancer risk across tissues was recently proposed to depend on the lifetime number of ASC divisions, owing to unavoi...
Adiposetissue is an abundant and easily obtainable source of adultmesenchymal stem cells(MSCs), which share similar characteristics to bone marrowMSCs, both in phenotypic marker identification and in functionality. Theseadiposestromal stem/progenitor cells (ASCs) are highly proliferative and possess the ...
Identification of functional tissue‐resident cardiac stem/progenitor cells in adult mousedoi:10.1042/CBR20120001cardiacstem/progenitorcellshistologicallocationlabelretainingcellregenerationIn most somatic tissues, ASCs (adult stem cells) are crucial for the maintenance of tissue homoeostasis under normal ...
The observations from our studies indicate that various molecular, genetic and epigenetic alterations take place in ASCs during the progression of age. These changes impact on proliferation and differentiation potential of tissue resident stem cells, and ultimately affect the tissue homeostasis and repair...
OMSCs have been reported by a number of authors [48,49,50] and as such cells are present in the lamina propria of the oral mucosa they are, unlike a number of other adult stem cells, easily accessed. OMSCs exhibit similar characteristics when isolated from young or aged donors and are mi...
These somatic stem cells exhibit shared fundamental behaviors, such as self-renewal, differentiation, quiescence, etc., which are regulated by both intrinsic cellular mechanisms and signals from specialized microenvironments. They serve as a group of resident cells with the ability to maintain tissue ...
A rich source of stem cells will be obtained from menstrual blood (Menstrual Blood Stem Cells: MenSCs). During the past decade the abundance, easy access, periodically and non-invasively collection, the ability to regularly donated, and autologous transplantation are the reasons that these cells ...
endogenous cells including tissue-resident stem cells and somatic cells, as well as progenitors recruited from the bloodstream, migrate, proliferate, and differentiate, whilst secreting new ECM to form vascular and neural networks at the injury site. Finally, the injured tissue gains restored physiologi...
To understand if their progenies elicit a wound-induced memory, we genetically labelled (GL) Lrig1+, Lgr5+ and Gata6+ HF cells (Extended Data Fig. 1a,b) in adult mice. We used a two-consecutive-injury model in tail skin (Fig. 1b) where, in the presence of a minimal tissue contrac...
Neurodegenerative diseases (NDs), such as Alzheimer’s disease (AD), are driven by neuroinflammation triggered by activated microglial cells; hence, the phenotypic regulation of these cells is an appealing target for intervention. Human adipose tissue-de