We reported here a new thiol-Michael addition based GSH response conjugate TC6, which consists of a unique tricyclic structure containing 伪, 尾-unsaturated ketone responsive groups. The conjugate was easily synthesized and showed good selectivity to glutathione with certain stability. The camptothecin ...
Thekey attribute of the thiol-Michael addition reaction that makesit a prized tool in materials science is its modular "click"nature, which allows for the implementation of this highly efficient,"green" reaction in applications that vary from smallmolecule synthesis to in situ polymer modifications ...
1. Phototriggered Base Amplification for Thiol-Michael Addition Reactions in Cross-linked Photopolymerizations with Efficient Dark Cure [J] . Sinha Jasmine, Podgorski Maciej, Tomaschke Andrew, Macromolecules . 2020,第15期 机译:具有高效黑色固化的交联光聚合中硫醇 - 迈克尔加法反应的光电触发基础扩增 ...
A reversible Michael addition reaction between thiol nucleophiles and cyanoenones has been previously postulated to be the mechanism‐of‐action of a new family of reversible covalent drugs. However, the hypothetical Michael adducts in this mechanism have only been detected by spectroscopic methods in ...
The organic/inorganic hybrid material of poly[2-(dimethyl amino)-ethyl methacrylate]/polyhedral oligomeric silsesquioxane (POSS-PDMAEMA) was synthesized via a thiol-Michael addition reaction. The structures of POSS-PDMAEMA and its self-assembly in aqueous solution were confirmed by H-1-NMR, TEM, ...
M. J. Well- Defined Single-Chain Polymer Nanoparticles via Thiol-Michael Addition. Polymer 2017, 120, 119-128.Kroger, A. P. P.; Boonen, R. J. E. A.; Paulusse, J. M. J. Well-Defined Single-Chain Polymer Nanoparticles via Thiol-Michael Addition. Polym. (United Kingdom) 2017, 120...
A new concept of photocrosslinking mechanism is developed to construct a 3D cell culture matrix based on a photouncaged-thiol Michael addition. This first-class approach not only provides highly cytocompatible gelation in a spatiotemporally controlled manner, but also controls gel stiffness via appropr...
The Michael addition-like thiol–ene reaction is a useful tool that can be used to tag proteins with high selectivity for the solvent-exposed thiol groups of proteins. To obtain insight into the bioconjugation of proteins with this method, a kinetic analysis was performed. New vinyl-substituted ...
Zhao Y, Ge ZM, Cheng TM, Li RT (2007) Thia-Michael addition using cheap and odorless S-alkylisothiouronium salts as thiol equivalents in water. Synlett 10: 1529–1532. : 10.1055/s-2007-982530Zhao Y, Ge ZM, Cheng TM, Li RT (2007) Thia-Michael addi- tion using cheap and odorless ...
Upon addition of tris (2-carboxyethyl) phosphine, the thiol-ene Michael addition reaction between GSH and AA was efficiently catalyzed, resulted in the quenched fluorescence triggered on. Under the optimum conditions, a linear detection range from 0.1 to 104μM was implemented for AA with a ...