Lastly, spatiotemporal control of both the thiol-ene reaction and thiol-Michael addition reaction were utilized to form a material with patterned functionalities and material properties, starting from a mixture of multifunctional thiols and an excess of multifunctional acrylates. This approach is based ...
Thekey attribute of the thiol-Michael addition reaction that makesit a prized tool in materials science is its modular "click"nature, which allows for the implementation of this highly efficient,"green" reaction in applications that vary from smallmolecule synthesis to in situ polymer modifications ...
A reversible Michael addition reaction between thiol nucleophiles and cyanoenones has been previously postulated to be the mechanism‐of‐action of a new family of reversible covalent drugs. However, the hypothetical Michael adducts in this mechanism have only been detected by spectroscopic methods in ...
机译:可见光引发的Thiol-Michael加成聚合与基于香豆素的光引发剂:另一种photoclick反应策略 7. Visible-Light-Initiated Thiol-Michael Addition Polymerizations with Coumarin-Based Photobase Generators: Another Photoclick Reaction Strategy [O] . Xinpeng Zhang, Weixian Xi, Chen Wang, 2016 机译:可见光引发...
2.2.2. Thiol-Michael addition A less common approach to the modification of polypeptides is the use of thiol-Michael addition reactions. This type of reaction is very common for small molecule or other types of polymer systems, but less typical for the main-chain functionalization of polypeptides...
The Michael addition-like thiol–ene reaction is a useful tool that can be used to tag proteins with high selectivity for the solvent-exposed thiol groups of proteins. To obtain insight into the bioconjugation of proteins with this method, a kinetic analysis was performed. New vinyl-substituted ...
Vinyl sulfone reacts with thiol groups by a Michael addition reaction. Thiol selectivity and water stability are the main advantages of this reagent, which has been frequently used for pegylation of proteins using vinyl sulfone PEG derivatives [92]. View chapter Chapter Post-translational ...
ChemInform Abstract: Thiol-Mediated Tandem Michael—Aldol Reaction: A Convenient Method for the Synthesis of Fused Cyclopentenonesindan derivativescycloaddition reactionsbenzofuran derivativesEsters of type (I) bearing a formyl group are treated with methyl thioglycolate in order to get thiopyrans of type...
Where sensitivity toward alkylation is assessed, iodoacetate or iodoacetamide are used rather than N-ethylmaleimide given the relative pH insensitivity of the Michael addition reaction occurring in the latter case [23,44]. Because pKa analysis can be complex and many factors can confound such ...
Main‐chain LCE networks were synthesized via a thiol‐acrylate Michael addition reaction. The robust nature of this reaction allowed for tailoring of the behavior of the LCEs by varying the concentration and functionality of the cross‐linker. The isotropic rubbery modulus, glass transition ...