CLOZAPINEAn analysis of patient data for individuals using clozapine for treatment‐resistant schizophrenia has identified a recommended therapeutic range of 250 to 550 ng/mL. Optimal benefits were seen at levels of at least 350 ng/mL, the investigators reported....
The clozapine serum level was 4034 microg/L, which was considered to be the primary cause of death. However, a forensic autopsy revealed unexpected metastases of unknown origin with gross liver involvement. Thus the high clozapine levels were judged to be secondary to liver failure. This case ...
Typical antipsychotic drugs qualify for therapeutic drug monitoring (TDM) primarily for the following reasons: control of compliance and avoidance of extrapyramidal side effects by keeping chronic exposure to minimal effective blood levels. For the atypical antipsychotic clozapine, drug safety is another re...
Patient had an improvement in symptoms with clozapine. In the third case, no improvement with CBD and partial improvement with olanzapine were observed, although clozapine was subsequently required. In case 3, mild improvement was reported with CBD in a patient who had previously failed to respond...
Mitochondrial dysfunction was linked to the adverse effects of antipsychotic drugs [12,13]. Some first-generation medicines—chlorpromazine, fluphenazine, and haloperidol—as well as second-generation—clozapine and risperidone—inhibited the activity of complex I in the brains of schizophrenia patients [...
The autophagy-mediated cell death was confirmed by the specific small interfering RNA (siRNA) of ATG5 and autophagy inhibitor 3-MA, whose cell death induced by itraconazole was partially inhibited in breast cancer cells. 5.3. Clozapine Another drug in repositioning is clozapine, which induces ...
Huntington’s disease (HD) is a paradigm of a genetic neurodegenerative disorder characterized by the expansion of CAG repeats in the HTT gene. This e
There have been no reports of agranulocytosis (as occurs with clozapine) or any other haemotoxicity attributed to olanzapine, and the drug has shown minimal effect on prolactin levels. Transient increases in levels of hepatic transaminases seem to be clinically important. The only events recorded ...
Concentrations of scheduled prescription drugs in blood of impaired drivers: ... AW Jones,A Holmgren,FC Kugelberg - 《Therapeutic Drug Monitoring》 被引量: 131发表: 2007年 Features and toxicokinetics of clozapine in overdose. Therapeutic Drug Monitoring . 1998Reith DM, Monteleone JP, Whyte IM, ...
A Puzzling Case of Increased Serum Clozapine Levels in a Patient With Inflammation and Infection Espnes, Ketil ArneHeimdal, Kent OveSpigset, Olav 489-492 False-Positive Amphetamine/Ecstasy (MDMA/3,4-Methylenedioxymethamphetamine) (CEDIA) and Ecstasy (MDMA/3,4-Methylenedioxymethamphetamine) (DRI) Tes...