CLOZAPINEAn analysis of patient data for individuals using clozapine for treatment‐resistant schizophrenia has identified a recommended therapeutic range of 250 to 550 ng/mL. Optimal benefits were seen at levels of at least 350 ng/mL, the investigators reported....
Will routine therapeutic drug monitoring have a place in clozapine therapy? Clozapine is an atypical antipsychotic medication with proven efficacy in the management of refractory schizophrenia. It is also recommended for patients w... DDJ Freeman,LK Oyewumi - 《Clinical Pharmacokinetics》 被引量: 177...
Utilizing plasma drug levels and genetic testing to achieve optimal treatment response in a patient with treatment‐resistant schizoaffective disorder We report the case of a Chinese male with schizoaffective disorder, an active smoker and a nonresponder to clozapine (600?mg daily). Therapeutic cl...
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature 350: 610–614. CAS PubMed Google Scholar Vijayraghavan S, Wang M, Birnbaum SG, Bruce CJ, Williams GV, Arnsten AFT (2006). Inverted-U dopamine D1 receptor actions on ...
Higher plasma drug concentration in clozapine-treated schizophrenic patients with side effects of obsessive/compulsive symptoms Lin, ShihKu;Su, ShengFen;Pan, ChunHung 303-307 Effects of caffeine on the kinetics of fluvoxamine and its major metabolite in plasma after a single oral dose of the dr...
4.Factors associated with non evidence-based prescribing of antipsychotics 机译:与非基于证据的抗精神病药处方相关的因素 作者:Anne Connolly;David Taylor 期刊名称:《Therapeutic Advances in Psychopharmacology》|2014年第6期 关键词: antipsychotic agents ethnology drug administration routes clozapine polypharmacy in...
(haloperidol, clozapine, thioridazine, pimozide, olanzapine) (Groos et al., 2018; Kobayashi et al., 2000) Ifenprodil (Kobayashi & Ikeda, 2006) Antidepressant drugs (partial antagonists)Paroxetine, milnacipran, trazodone GIRK1/2, GIRK1/4 and GIRK2 channels (Kobayashi et al., 2006b) Tipepidine...
Weight gain is a commonly observed adverse event for treatment with phycotropic drugs. The most pronounced effect seen is probably the weight gain associated with antipsychotics, such as clozapine and olanzapine, but clinically relevant weight gain is also observed for antidepressants [Exp. Opin. Phar...
Use of lamotrigine to augment clozapine in patients with resistant schizophrenia and comorbid alcohol dependence: a potent anti-craving effect? J Psychopharmacol 19: 301–305. Kampman KM, Pettinati H, Lynch KG, Dackis C, Sparkman T, Weigley C et al (2004). A pilot trial of topiramate for...
In healthy subjects, acute pretreatment with 5 mg of haloperidol, 25 mg of clozapine, and 5 mg of olan- zepine did not significantly reduce positive or negative symptoms produced by NMDA antagonists (Krystal et al. 1999b; Lipschitz et al. 1997). The findings with typical neuroleptics in ...