The following arguments are presented: (i) because of a great interindividual variability of the clozapine concentration to dose ratio (C/D) it can be calculated that extremely high daily doses (900 to 1800 mg/day) would be necessary in 15% of patients to obtain a clozapine concentration of...
Will routine therapeutic drug monitoring have a place in clozapine therapy? Clozapine is an atypical antipsychotic medication with proven efficacy in the management of refractory schizophrenia. It is also recommended for patients w... DDJ Freeman,LK Oyewumi - 《Clinical Pharmacokinetics》 被引量: 177...
Among all facilities surveyed, lithium was the most common psychotropic drug (68.1% of the laboratories) monitored by TDM, followed by clozapine (44.7%), carbamazepine (25.5%), chlorpromazine (21.3%), norclozapine (19.1%), risperidone (19.1%), paliperidone (17.0%), valproic acid (14.9%), ...
Clozapine nevertheless fulfils a number of criteria which make it a candidate for therapeutic monitoring. These include an identifiable therapeutic range, an unpredictable dose-concentration relationship between patients, a potential for clinically relevant pharmacokinetic interaction with other drugs and a ...
Higher plasma drug concentration in clozapine-treated schizophrenic patients with side effects of obsessive/compulsive symptoms Lin, ShihKu;Su, ShengFen;Pan, ChunHung 303-307 Effects of caffeine on the kinetics of fluvoxamine and its major metabolite in plasma after a single oral dose of the dr...
We report the case of a Chinese male with schizoaffective disorder, an active smoker and a nonresponder to clozapine (600?mg daily). Therapeutic clozapine ... Jin‐jie Xu,Chunfeng Xiao,Yanli PanYi‐lang TangMingwan WangSheng LiGaoming XieJing DuYanping RenWei Wang - 《Bipolar Disorders》 被...
Among all facilities surveyed, lithium was the most common psychotropic drug (68.1% of the laboratories) monitored by TDM, followed by clozapine (44.7%), carbamazepine (25.5%), chlorpromazine (21.3%), norclozapine (19.1%), risperidone (19.1%), paliperidone (17.0%), valproic acid (14.9%), ...
The treatment of other types of psychogenic catatonia should follow the guidelines for the treatment of the underlying psychiatric condition. Antipsychotic-induced catatonia necessitates the use of anticholinergics, dose reduction of antipsychotics or change to clozapine. In patients with neuroleptic ...
Routine monitoring is very important, particularly for medications with narrow reference levels and high adverse effect potential, such as clozapine or lithium. Controlling for drug adherence is another essential factor. Therapeutic references for psychotropic medications (if available) are population-based,...
the second group took 25 g of activated charcoal immediately after pholcodine; the third group received 25 g of activated charcoal 2 h and the fourth group 5 h after ingestion of the 100-mg dose of pholcodine. In addition, the fourth group received multiple doses (10 g each) of charcoal...