In children and adolescents, however, the relationships between risperidone dose and blood concentrations have not been clarified yet and age-specific recommended reference ranges of blood concentrations have not been defined for the different age or diagnostic groups. The few existing pharmacokinetic studi...
Randomised controlled trials and population observational studies have shown that the risk of developing diabetes differs markedly between the various compounds: higher risk for clozapine or olanzapine; intermediate risk for risperidone and quetiapine; lowest risk for aripiprazole, which has a different ...
Antipsychotics for which TDM is strongly recommended (level 1 recommendation) include clozapine, fluphenazine, haloperidol, olanzapine, perazine and perphenazine [4]. For these drugs, blood level within the therapeutic range is associated with favorable clinical outcomes in terms of efficacy, as well ...
The CYP2A6 participates in the metabolisms of many drugs that could be used in the post-acute sequelae phase of SARS-CoV-2 infection (e.g., vortioxetine, clozapine, amiodarone) [53]. The CYP2A6 variants such as the rs5031016 which comprised the CYP2A6*7 allele with AF of 13.0% and rs...
However, a meta-analysis on the pooled dataset (AD) failed to find a better effect of clozapine when compared to other second-generation antipsychotics, instead revealing considerable differences between trials and variations in treatment effectiveness among patients. We will use an individual particip...
formation, thereby synergistically enhancing the therapeutic efficacy of CiSP in this cancer type [144]. Recently, Xing et al.. found that TRPM7 inhibits autophagy in cancer cells, and treatment with TRPM7 chemical agonists (clozapine or naltriben) suppresses tumor growth and metastasis in vivo [...
Routine monitoring is very important, particularly for medications with narrow reference levels and high adverse effect potential, such as clozapine or lithium. Controlling for drug adherence is another essential factor. Therapeutic references for psychotropic medications (if available) are population-based,...
In addition, co-administration of VPA with antipsychotics (eg, clozapine[187], olanzapine and quetiapine) can synergistically potentiate VPA-induced promoter demeth- ylation and chromatin remodeling (see review by[49]) and enhance antipsychotic effects[188]. VPA can elevate GABA con- centration via...
In case 3, mild improvement was reported with CBD in a patient who had previously failed to respond to olanzapine, clozapine, or haloperidol decanoate. These results suggest a limited role of CBD in treatment-resistant schizophrenia (Zuardi et al., 2006). The dose were not individually ...
(haloperidol, clozapine, thioridazine, pimozide, olanzapine) (Groos et al., 2018; Kobayashi et al., 2000) Ifenprodil (Kobayashi & Ikeda, 2006) Antidepressant drugs (partial antagonists)Paroxetine, milnacipran, trazodone GIRK1/2, GIRK1/4 and GIRK2 channels (Kobayashi et al., 2006b) Tipepidine...