doi:10.1055/s-0044-1779574Kuzo, N.Piras, M.Lutz, U. C.Haen, E.Eap, C. B.Hiemke, C.Paulzen, M.Schoretsanitis, G.Pharmacopsychiatry
There is a wide range of them, from agents affecting the nervous system with high toxicity and narrow therapeutic windows such as those for the treatment of depressive and anxiety disorders to the OTC drugs such as acetaminophen and aspirin. We also detected novel variants with high frequency in...
Simultaneous determination of clozapine, olanzapine, risperidone and quetiapine in plasma by high-performance liquid chromatography-electrospray ionization... Conclusion: The method is accurate, sensitive and simple for routine therapeutic drug monitoring (TDM) and for the study of the pharmacokinetics of ...
Together, these results show the importance of an optimal range of GirK signaling for normal hippocampus-dependent cognition (Sánchez-Rodríguez et al., 2020; Victoria et al., 2016). 4. GirK currents are modulated by G-protein coupled receptors A wide variety of neurotransmitters and neuro...
How- ever, for unclear reasons, benefits of glycine-B agonists may not be observed when added to clozapine (Goff et al. 1996). There is also great interest in studying the clinical efficacy of glycine transporter antagonists in hu- man laboratory paradigms and treatment of schizo- phrenic ...
dementia. This positive outcome is possibly associated with a significant loss of cholinergic projections from the nucleus basalis of Meynert in dementia.217,231For psychotic symptoms in PD, clozapine is the most effective therapy. Finally, autonomic dysfunction is quite common in PD, especially ...
The effect size for this association was significantly greater for positive than negative symptoms of psychosis (estimate, 0.36 [95% CI, 0.12-0.61]; P = .004). There was significant inconsistency in outcomes between studies (I2 range, 77%-83%). Bolus followed by constant in...
Multiple recent studies have found promising clinical benefits of psychedelic substances for a wide range of mental illnesses, including end-of-life anxiety, treatment resistant depression, post-traumatic stress disorder (PTSD), and substance use disorders. While the pharmacodynamic and neurological ...
Weight gain is a commonly observed adverse event for treatment with phycotropic drugs. The most pronounced effect seen is probably the weight gain associated with antipsychotics, such as clozapine and olanzapine, but clinically relevant weight gain is also observed for antidepressants [Exp. Opin. Phar...
an antipsychotic agent for example olanzapine and clozapine; a serotonin receptor modulator; a leptin/leptin receptor modulator; a ghrelin/ghrelin receptor modulator; a DPP-IV inhibitor; or a pharmaceutically acceptable salt, solvate, solvate of such a salt or a prodrug thereof, optionally ...