doi:10.1055/s-0044-1779574Kuzo, N.Piras, M.Lutz, U. C.Haen, E.Eap, C. B.Hiemke, C.Paulzen, M.Schoretsanitis, G.Pharmacopsychiatry
Clozapineis the seminalatypical antipsychoticthat despite significantside effects, e.g.,agranulocytosis, remains the most effective of the compounds in its therapeutic class, being used for the treatment of resistant schizophrenics or those intolerant of conventional antipsychotic medications[209]. For th...
Therapeutic Use Noncomparative studies in hospitalised patients with schizophrenia have indicated that clozapine produces symptomatic improvement in 60 to 80% of cases, with the benefit being most evident in those with acute schizophrenia. Typically, the response to clozapine is characterised by an initia...
bradycardia, and syncope [seeWARNINGS AND PRECAUTIONS]. If that dose is well-tolerated, the dose may be increased to the previously therapeutic dose more quickly
Therapeutic Efficacy The efficacy of clozapine in patients with schizophrenia who are unresponsive to or intolerant of classical antipsychotic agents has been demonstrated in both open noncomparative trials and randomised double-blind comparative trials against classical antipsychotic agents. Response rates to...
re-initiate with 12.5 mg once daily or twice daily. This is necessary to minimize the risk of hypotension, bradycardia, and syncope [seeWARNINGS AND PRECAUTIONS]. If that dose is well-tolerated, the dose may be increased to the previously therapeutic dose more quickly than recommended for initi...
Inhibition assays showing the relative activity (%) of recombinant human DDO in the presence of different concentrations (1–1000 μM range) of first- (chlorpromazine, haloperidol) and second-generation antipsychotic (clozapine, olanzapine), and antidepressant drugs (amitriptyline, bupropion, ...
Clozapine: why is it so uniquely effective in the treatment of a range of neuropsychiatric disorders? Biomolecules, 11 (7) (2021) Google Scholar Green et al., 2008 A.I. Green, D.L. Noordsy, M.F. Brunette, C. O’Keefe Substance abuse and schizophrenia: Pharmacotherapeutic intervention J...
Discussion Compared with other neuroleptics, clozapine appears to cause more seizures at therapeutic doses than the most epileptogenic of standard antipsychotic agents.4 The mecha- nism of clozapine-induced seizure is not well understood. Typical antipsychotic drugs primarily target striatonigral dopamine...
previous antipsychotic therapy, no reliable aetiological or clinical predictors of therapeutic response to clozapine in treatment-resistant schizophrenia have been identified. Clozapine is distinguished from standard antipsychotics by its relatively low incidence of extrapyramidal effects, of which akathisia, ...