2014). The pathway is evolutionarily conserved in metazoans and the components of the signaling cascades have been well-defined based on the study from various systems and genetic organisms, especiallyDrosophila(Clevers,2006; Moon et al.,2002; van Amerongen...
The Hippo signaling pathway Fig. 2: Schematic of the Hippo signaling pathway and the interaction between lncRNAs and the pathway. After receiving the upstream signals, the core kinase combination, including LATS1, LATS2, MST1, MST2, SAV1, and MOB1, are activated and cooperate to phosphorylate...
et al. PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures. Frontiers in immunology. 2012;3:307 6. Thomas GM, Carbo C, Curtis BR, Martinod K, Mazo IB, Schatzberg D. et al. Extracellular ...
X. G. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 137, 216–233 (2009). Article CAS PubMed PubMed Central Google Scholar Aster, J. C., Pear, W. S. & Blacklow, S. C. The varied roles of notch in cancer. Annu. Rev. Pathol. 12, 245–275 (...
In addition or instead, unfolding of the C-terminal helical domain may expose the nuclear export signal and thereby facilitate Merlin's exit from the nucleus. Interestingly, other FERM domain proteins, such as the isoforms H and R of band 4.1 and FAK, appear to shuttle in and out of the ...
Kopan, R. & Ilagan, M. X. G. The canonical NOTCH signaling pathway: unfolding the activation mechanism.Cell137, 216–233 (2009). CASPubMedPubMed CentralGoogle Scholar Ntziachristos, P., Lim, J. S., Sage, J. & Aifantis, I. From fly wings to targeted cancer therapies: a centennial...
Unfolding protein response CMJ: Cortical-medullary junction cTEC: Cortical thymic epithelial cell mTEC: Medullary epithelial cell TRAs: Tissue restricted antigens ECM: Extracellular matrix Fb: Fibroblast CapFb: Capsular fibroblast mFb: Medullary fibroblast MSC: Mesenchymal stem cells MEx: ...
et al. Protein-dependent membrane interaction of a partially disordered protein complex with oleic acid: implications for cancer lipidomics. Sci. Rep. 6, 35015 (2016). CAS PubMed PubMed Central Google Scholar Svensson, M. et al. α-Lactalbumin unfolding is not sufficient to cause apoptosis,...
During the latter process, many different phenomena at the cellular level (e.g. cell shape changes, cell migration, folding and unfolding of epithelial sheets) contribute to the drastic changes observed in size and shape. Because of this complexity, the logic behind the formation of the 3D ...
actin filaments, possibly through an alternative actin-binding site. ERM proteins such as merlin exhibit self-regulation through binding of the head and tail of the protein, with folding and unfolding regulated by phosphorylation of the C-terminus. Despite its homology to other ERM proteins and int...