22.Seo E,Kim WY,Hur J,et al.The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis[J].Sci Rep,2016,6:31931.DOI:10.1038/srep31931. 23.Elaimy AL,Mercurio AM.Convergence of VEGF and YAP/TAZ ...
Finally, PCP, another type of cell polarity, also functions as an upstream signal of the Hippo pathway. It has been demonstrated that PCP is regulated by the protocadherins Fat (Ft) and Dachsous (Ds),76,77which are involved in the regulation of the Hippo pathway.78,79Through the Golgi-re...
10. Sebio A, et al. Molecular Pathways: Hippo Signaling, a Critical Tumor Suppressor. Clin Cancer Res. 2015; 21(22): 5002-5007. 11. Run Fan, et al. Regulation of Hippo pathway by mitogenic growthfactors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1. Proc Natl Acad ...
andoropharyngeal cancers[4]. In this review, we focused to summarize the Hippo signal transduction pathway, its main components, its status in different types of cancers, its role in maintaininghomeostasis, chemoresistance, its regulation by othersignaling pathwaysandmiRNAsand finally the different way...
Hepatology. 2020; 72(1): 72-87.4. Xu L, et al. SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling [published online ahead of print.Protein Cell. 2020 Jul 13. 5. Calses PC, et al. Hippo Pathway in Cancer: Aberrant Regulation and ...
and organ size through the regulation of cell proliferation and apoptosis [1,2,3]. Increasing studies confirm that the hippo signaling pathway is involved in regulating a variety of physiological processes in the human body, and its dysfunction leads to uncontrolled cell growth and even malignant ...
19. DeRan M, et al. Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein. Cell Rep. 2014; 9(2): 495-503. 20. Pobbati AV, et al. A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy. Theranostics. 2020; 10(8): 3622-36...
(1):27.10. Sebio A, et al. Molecular Pathways: Hippo Signaling, a Critical Tumor Suppressor. Clin Cancer Res. 2015; 21(22): 5002-5007.11. Run Fan, et al. Regulation of Hippo pathway by mitogenic growthfactors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1. Proc Natl...
Intersection of Hippo/YAP and Wnt/β- catenin signaling pathways. Acta Biochim Biophys Sin (Shanghai). 2013;45:71-79. doi: 10.1093/abbs/gms084.Konsavage, W. M. & Yochum, G. S. Intersection of Hippo/YAP and Wnt/β-catenin signaling pathways. Acta Biochim Biophys Sin (Shanghai) 45...
TheHippo/ YAPsignalingpathwayhasbeenfoundtofunctionallyinteractwithmanyothercellularpathwaysandactasacentralnodeintheregulationofcelldivisioninvariouscancers. ThereforeꎬthestudyoftheexpressionquantityofHipposignalingpathwaymajoreffectorproteinsincancercellscanhelptoexplorethenatureꎬoccur~renceanddevelopmentoftumors....