通过GO功能分析发现,GO生物过程中含有与细胞凋亡(标红)、增殖(标蓝)、迁移(标黑)相关的Term(图4B),这与上述研究结果一致。经KEGG富集分析发现,Hippo signaling pathway是p值最小的信号通路(图4C),表明该通路可能在虫草素治疗肝癌中发挥重要作用。我们将所有的差异基因与Hippo信号通路相关的基因做富集分析,发现共有...
KEGG Hippo signaling pathway.Damien, ReadyKader, YagizPooneh, AminYuksel, YildizVincent, FunariSerdar, BozdagBekir, Cinar
国自然和SCI实验设计的必备技能:快速查询基因和通路的关系! 1257 -- 1:01 App 信号通路中必知的概念! 3.6万 2 4:09 App 富集分析是什么?GO vs KEGG:初中生都能看懂! 2.8万 21 10:30 App Wnt通路 2332 -- 4:51 App Wnt信号通路 浏览方式(推荐使用) 哔哩哔哩 你感兴趣的视频都在B站 打开信息...
摘要 The Hippo kinases MST1 and MST2 initiate a highly conserved signaling cascade called the Hippo pathway that limits organ size and tumor formation in animals. Intriguingly, pathogens hijack this host pathway during infection, but the role of MST1/2 in innate immune cells against pathogens is...
2.13. Pathway Enrichment Analysis The data were downloaded from GEO database (GSE47179). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was used to determine the associated biological pathways after PCAF silence. In addition, the DAVID online tool was applied to KEGG pathway analys...
作者使用RNA seq检测了4中稳转载体的DLD-1细胞中RNA的变化,并对差异表达基因进行了KEGG pathway 富集分析,Hippo通路是富集最显著的通路。YAP1作为Hippo信号通路中重要的转录共激活因子,YAP1诱导的转录反应在癌细胞的增殖和转移中发挥关键作用。 为了确认YAP1激活是否在circPPP1R12A-73aa诱导的癌细胞生长和转移中扮演...
作者使用RNA seq检测了4中稳转载体的DLD-1细胞中RNA的变化,并对差异表达基因进行了KEGG pathway 富集分析,Hippo通路是富集最显著的通路。YAP1作为Hippo信号通路中重要的转录共激活因子,YAP1诱导的转录反应在癌细胞的增殖和转移中发挥关键作用。 为了确认YAP1激活是否在circPPP1R12A-73aa诱导的癌细胞生长和转移中扮演...
(https://tcga-data.nci.nih.gov).CTCGA database analysis showed a significant positive correlation between the expression levels of CXCR7 and Hippo pathway target genes in gastric cancer samples.DRNA-seq data analysis indicated the top 10 KEGG pathways enriched by CXCR7 depletion in MGC803 ...
一项关于靶向作用于 Hippo 信号通路的 miRNA 测序结果显示,在差异表达的 96 个促心肌细胞增殖的 miRNA 中,有 84 个 miRNA 可诱导 YAP 核易位,且其中大多数 (67/84) miRNA 引起的增殖效应需要 YAP 参与 .[51] 经过 KEGG 富集信 号通路后发现,Hippo 信号通路参与了 miRNA 的促心肌增殖作 用,这可能与多个 ...
The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program Genes Dev., 24 (2010), pp. 2383-2388 Crossref View in Scopus Google Scholar Cai et al., 2015 J. Cai, A. Maitra, R.A. Anders, M.M. Taketo, D. Pan ...