Regulation of hippo signaling mediated apoptosis by Rauvolfia tetraphylla in triple-negative breast cancerAnti-proliferative effectHippo pathwayMDA-MB-231 cellsApoptosisRauvolfia tetraphyllaPATHWAYYAPGROWTHEXTRACTSPLANTSRauvolfia tetraphylla is an essential medicinal plant that has been widely used in traditional...
Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors. Dev Biol 2011;350:139-51.Sun G, Irvine KD (2011) Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and...
EGFR and Hippo signaling pathways both control growth and, when dysregulated, contribute to tumorigenesis. We find that EGFR activates the Hippo pathway transcription factor Yorkie and demonstrate that Yorkie is required for the influence of EGFR on cell proliferation in Drosophila. EGFR regulates Yorkie...
Besides, depletion of YAP in TNBC cell lines inhibited cell invasion and proliferation in both in vitro and in vivo3,15,16,17. All these studies indicated that Hippo activation is an important driving force for TNBC progression. Since YAP signaling was shown to be critical in cancer progression...
Phosphorylation of cytoplasmic YAP1 and/or its paralogue WWTR1 by kinases of the Hippo pathway inhibits YAP1’s translocation to the nucleus where it activates target genes important for cell proliferation, cell death and cell motility4,5. Recent studies highlight a critical role of Hippo-YAP1 ...
apoptosis of Tca8113 cells.Under hypoxic condition, the expression levels of HIF-1α and TAZ at both mRNA and protein levels were significantly increased (p Under hypoxic conditions, HIF-1α inhibits the proliferation and apoptosis of Tca8113 cells via the elevation of the Hippo signaling pathway...
The Hippo pathway is crucial in organ size control and tumorigenesis. Dysregulation of the Hippo/YAP axis is commonly observed in gastric cancer, while effective therapeutic targets for the Hippo/YAP axis are lacking. Identification of reliable drug targ
Thus, GPCR signaling can either activate or inhibit the Hippo-YAP pathway depending on the coupled G protein. Our study identifies extracellular diffusible signals that modulate the Hippo pathway and also establishes the Hippo-YAP pathway as a critical signaling branch downstream of GPCR. Graphical ...
Consistent with this high- to low-NE transition, we detected a significant gain in the expression of multiple Hippo signaling targets (YAP1, TEAD2, AJUBA, CYR61, WWTR1) and NOTCH targets (HES1 and HEY1) upon treatment in both models (Fig. 2E, F). GSEA confirmed the activation of ...
(Fig.5h), is relevant to the regulation of cardiovascular circadian rhythms52. Additionally,LIMD1, whose functions are associated with the regulation of hippo signaling53and the response to hypoxia54, was up-regulated in the hypothalamus in high-altitude Hu sheep due to open accessibility (Fig....