In mammalian and Drosophila cells, Ajuba LIM proteins/dJub interact with LATS/Warts (Wts) and WW45/Sav to inhibit phosphorylation of YAP/Yki. This work describes a novel role for the Ajuba LIM proteins as negative regulators of the Hippo signaling pathway. Highlights ► djub is an essential...
Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling . Mol Cell 39 :521–534. doi:.10.1016/j.molcel.2010.08.002 [ Cross Ref ]Ribeiro PS, Josué F, Wepf A et al (2010) Combined functional genomic and proteomic approaches ...
Interestingly, Our clinical data reveals that RNF187 reversely correlates with YAP protein level and Hippo target genes. RNF187 tends to correlate with good prognosis in TNBC patients. Our study provides evidence to establish a proteolytic mechanism in regulation Hippo signaling activation in TNBC....
catalytic activity acting on RNA endocardial cushion morphogenesis extracellular transport negative regulation of gluconeogenesis ciliary basal body steroid harmone biosynthetic process DOWN gene set size 100 200 300 FDR 0.5 0.4 0.3 -1.85 -1.80 -1.75 -1.70 -1.65 normalized enrichment score d appetitive...
An important regulator of organ size and tumorigenesis is the Hippo pathway. Recent studies have unveiled increasing complexity in regulation of Hippo path... CLC Poon - 《Science Signaling》 被引量: 0发表: 0年 Subcellular localization of proteins governing the proteolytic activation of a development...
As for the combination treatment groups, we observed that low-dose combination resulted in a lower degree of EMT gene-set upregulation compared to that under palbociclib monotherapy, while no upregulation of the EMT gene set was detected in high-dose combination treatment group of any of the th...
Cancer stem cells (CSCs) are a small population of cells in tumor tissues that can drive tumor initiation and promote tumor progression. A small number of previous studies indirectly mentioned the role of F-box and WD repeat domain-containing 7 (FBXW7) a
LINC00673 is activated by YY1 and promotes the proliferation of breast cancer cells via the miR-515-5p/MARK4/Hippo signaling pathway [23]. On the other hand, the nuclear lncRNAs could regulate gene expression by participating in several biological processes, such as chromatin organization, nuclear...
Transcription and processing: multilayer controls of RNA biogenesis by the Hippo pathway. EMBO J. 2014;33(May 2):942–4. Article CAS Google Scholar Meng Z, Moroishi T, Guan KL. Mechanisms of Hippo pathway regulation. Genes Dev. 2016;30(Jan 1):1–17. Article CAS Google Scholar Cal...
Significantly, we have discovered that LATS1 inactivates YAP oncogenic function by suppressing its transcription regulation of cellular genes via sequestration of YAP in the cytoplasm after phosphorylation of YAP. Finally, by using microarray analysis, we have also identified many oncogenes or tumor ...