Different groups of scientists indicated that yes-associated protein and transcriptional coactivator with PDZ-binding motif, which are the main effectors of the Hippo pathway, are the center in the development of PDAC. Here, we will focus on the recent advances of the molecular mechanisms of core...
In order to gain a comprehensive understanding of the impact of the Hippo pathway on lung cancer, we conducted a search for articles related to the Hippo pathway and lung cancer on the Web of Science Core Collection (Supplementary MaterialS1provides the keywords used in the search). A total o...
Hippo pathway effector Yap promotes cardiac regeneration. Proc. Natl Acad. Sci. USA 110, 13839–13844 (2013). Article CAS PubMed PubMed Central Google Scholar Leach, J. P. et al. Hippo pathway deficiency reverses systolic heart failure after infarction. Nature 550, 260–264 (2017). ...
Neonatal CPCs, in particular, exhibited characteristics indicative of early cardiovascular development and enhanced proliferative capacity, alongside a significant downregulation of the Hippo signaling pathway effector gene Yap1. Conversely, adult CPCs showed an upregulation of Yap1 under microgravity, as ...
This modification is implicated in various cellular processes, such as signal transduction, cell cycle regulation, transcriptional control, and metabolism [4,5,6,7]. Roughly 2–5% of glucose feeds into the hexosamine biosynthetic pathway (HBP) to generate UDP-GlcNAc, the sugar donor for O-...
[85]. They found that the recurrent CRC group showed 4,787 differential methylated genes with 3,112 hypermethylated and 1,675 hypomethylated compared to the non-recurrence group. The hypermethylated genes were linked to the MAPK signaling pathway which is involved in the regulation of apoptosis ...
Deregulation of the Hippo pathway which primarily regulates the growth of organs can result in the widespread incidence of tumors [91]. It has been revealed that the Hippo pathway hinders tumor signaling cascades by regulating the tumor suppressor YAP/TAZ through a restriction in organ size [92]...
Within mature cardiomyocytes, mitochondria account for one-third of the total cell volume. Moreover, they are relatively stable structures and closely related to sarcoplasmic reticulum and myofibrils, enabling them to provide energy in the form of ATP and creatine and contribute to Ca2+ regulation [...
A structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (WD) dipeptide. Planarians Flatworms used as a model system to study regeneration. Hippo pathway A signalling pathway that controls organ size in animals by restraining cell proliferation and promoting...
on the SLC7A11 subunit of System Xc-, the antioxidant system in the body is imbalanced, ultimately leading to the accumulation of lipid peroxidation and cell death. In addition, another pathway has been found to induce ferroptosis in EHS. The Hippo-YAP signaling pathway targets ACSL4 to ...