LncRNA SFTA1P mediates positive feedback regulation of the Hippo-YAP/TAZ signaling pathway in non-small cell lung cancerLong non-coding RNAs (lncRNAs) regulate numerous biological processes involved in both development and carcinogenesis. Hippo-YAP/TAZ signaling, a critical pathway responsible for ...
Upregulation of upstream signaling pathways is attributed to molecules produced in the tumor microenvironment; it causes constitutive activation of STAT3 and promotes cell proliferation (such as cyclin D-1, c-Myc), apoptosis (such as Bcl-2, survivin), immunosuppression (such as IL-10), inflammatio...
Hippo通路通过Yki-Src42A-JNK轴抑制肿瘤细胞迁移的机制探究 随着人们对肿瘤迁移的认识不断深入,通过抑制肿瘤的迁移控制癌症的发展被逐渐重视起来.同时癌症的发展与信号通路密切相关,通过加深对信号通路的研究,希望找到关键的治... 丁燕,生物学 - 《山东农业大学》 被引量: 0发表: 0年0...
neutral neurotransmetter receptor complex glutamate receptor sigaling pathway olfactory receptor activity cell body membrane ionotropic glutamate receptor activity sensory perception of smell glutamate receptor activity chemokine receptor binding regulation of ampa receptor activity immunoglobulin binding regulation ...
A review: hippo signaling pathway promotes tumor invasion and metastasis by regulating target gene expression. J Cancer Res Clin Oncol. 2021;147:1569–85. Article PubMed Google Scholar Zanconato F, Cordenonsi M, Piccolo S. YAP and TAZ: a signalling hub of the tumour microenvironment. Nat ...
Results found that miR-550a-3-5p was related to the cytokine, chemokine activity, and Hippo signaling pathway (Supplementary Fig. 3D). As recent studies demonstrated critical functions of Hippo signaling in cancer immunity [27], we firstly detected expressions of its central transcription factors,...
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat Chem Biol. 2013;9:677–84. Article CAS Google Scholar Pei XD, et al. alpha-Cyperone inhibits the proliferation of human cervical cancer HeLa cells via ROS-mediated PI3K/Akt/mTOR signaling pathway. Eur J Pharmacol...
Here we show that the APC CID interacts with α-catenin, a Hippo signaling regulator and heterodimeric partner of β-catenin at cell:cell adherens junctions. Importantly, α-catenin promotes β-catenin ubiquitylation and proteolysis by stabilizing its association with APC and protecting the ...
In conclusion, to the best of our knowledge, this is the first study demonstrating that miR-378a-5p acts as an oncogenic microRNA in melanoma.Similar content being viewed by others Regulation of melanoma malignancy by the RP11-705C15.3/miR-145-5p/NRAS/MAPK signaling axis Article Open ...
The Drosophila Hippo pathway inhibits transcription of a microRNA bantam that plays an important role in regulation of cell proliferation, apoptosis, stem cell self-renewal and organ size [36-38]. However, bantam is not conserved in mam- mals and a mammalian functional counterpart of bantam is ...