substantial efforts have been made to understand the upstream signals that influence the activity of the Hippo pathway, as well as its physiological functions, such as cell proliferation and differentiation, organ growth, embryogenesis, and tissue...
The Hippo signaling pathway interactome. Science 2013; 342: 737–740. 118. Wang W, Xiao Z-D, Li X, Aziz KE, Gan B, Johnson RL et al. AMPK modulates Hippo pathway activity to regulate energy homeostasis. Nat Cell Biol 2015; 17: 490–499. 119. Mo J-S, Meng Z, Kim YC, Park HW...
4C). Among the cancer pathways, the Hippo signaling pathway was the most obviously enriched for the DEGs. That is, numerous well-characterized TAZ/YAP target genes were found to be downregulated in the RNA-seq dataset in Sec C-treated group (data not shown), indicating that YAP activity ...
Hippo protein interactome that was analyzed by using affinity purification coupled to mass spectrometry [19]. Okadaic acid treatment promoted interactions of MOB1A/1B and PP6 holoenzymes [19]. In yeast Mob1, three basic amino acids that form part of a phospho-Ser/Thr-binding pocket are ...
Halder, Discovering the Hippo pathway protein-protein interactome, Cell Res. 24 (2014) 137-138.Moya IM, Halder G. Discovering the Hippo pathway protein-protein interactome. Cell Res 2014;24:137-8.Moya IM, Halder G: Discovering the Hippo pathway protein-protein interactome. Cell Res 2014;24:...
The activation of the Hippo pathway in HPCs is essential for HCC development (Meng et al. 2021). High expression of the zinc finger protein ZEB1 promotes the differentiation of tumor-associated macrophages into cancer-promoting macrophages (M2) by upregulating CD74 expression in tumor cells, thus...
Deregulation of its expression or localization leads to epithelial defects and tumorigenesis in part as a consequence of its repressive role on several signaling pathways including AKT, ERK and HIPPO. In the present work, we used a proteomic approach to characterize the protein complexes associated ...
MiR-591 functions as tumor suppressor in breast cancer by targeting TCF4 and inhibits Hippo-YAP/TAZ signaling pathway. Cancer Cell Int. 2019;19:108. https://doi.org/10.1186/s12935-019-0818-x. Article PubMed PubMed Central Google Scholar Ji C, Hong X, Lan B, et al. Circ_0091581 ...
The striatin-interacting phosphatase and kinase (STRIPAK) complex is a large, multisubunit protein phosphatase 2A (PP2A) assembly that integrates diverse cellular signals in the Hippo pathway to regulate cell proliferation and survival. The architecture
The Hippo pathway plays an important role in organ development and adult tissue homeostasis, and its deregulation has been implicated in many cancers. The Hippo signaling relies on a core kinase cascade culminating in phosphorylation of the transcription