NLRP3 is considered to be a sensor of microbial and other danger signals and plays a crucial role in immune responses, dysregulation of NLRP3 inflammasome activation is involved in skin diseases. With the in-depth research, targeting NLRP3 inflammasome and its downstream signaling will provide new...
The role and regulatory mechanisms of NLRP3 inflammasomes in aging Immunosenescence, characterized by the declining ability of the immune system to effectively respond to pathogens and cancer cells during aging, is a critical aspect of age-related changes. Chronic low-grade inflammation has been consis...
The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human health. Researchers are dedicated to understanding and coping with the complexities of aging, constantly uncovering the substances and m
Our results showed that hypoxia also induced the secretion of IL-1尾 in PC3, BPH-1 and RWPE-1 cells. Third, we found that NLRP3 inflammasome activation involved in regulating tumor growth and metastasis. Our results indicated that the activation of NLRP3 inflammation plays an important role ...
An intense, stereotyped inflammatory response occurs in response to ischaemic and non-ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome is a finely regulated macromolecular protein complex that s
Abstract. The Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome has been the most distinctive polymer protein complex. After recogniz
Among them, the NLR family pyrin domain containing 3 (NLRP3) inflammasome has been studied the most, and the specific mechanisms of its activation and regulation are complex [17], [18], [19]. Studies have shown that the NLRP3 inflammasome plays an important role in the digestive, ...
The nucleotide-binding and oligomerisation (NOD) domain-like receptor (NLR) family pyrin domain (PYD)-containing 3 (NLRP3) inflammasome is a protein complex and a vital component of the immune system. Emerging evidence has indicated that the NLRP3 inflammasome plays an important role in ...
NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders Article Open access 01 July 2024 References Hotamisligil, G.S. Inflammation and metabolic disorders. Nature 444, 860–867 (2006). Article CAS PubMed Google Scholar Fève, B. & Bastard, J.P. The role of inte...
The NLRP3 inflammasome is a multiprotein platform which is activated upon cellular infection or stress. Its activation leads to caspase-1-dependent secretion of proinflammatory cytokines like interleukin-1尾 (IL-1尾) and IL-18, and an inflammatory form of cell death termed as pyroptosis. Recent ...