An intense, stereotyped inflammatory response occurs in response to ischaemic and non-ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome is a finely regulated macromolecular protein complex that s
NLRP3 is considered to be a sensor of microbial and other danger signals and plays a crucial role in immune responses, dysregulation of NLRP3 inflammasome activation is involved in skin diseases. With the in-depth research, targeting NLRP3 inflammasome and its downstream signaling will provide new...
The role and regulatory mechanisms of NLRP3 inflammasomes in aging Immunosenescence, characterized by the declining ability of the immune system to effectively respond to pathogens and cancer cells during aging, is a critical aspect of age-related changes. Chronic low-grade inflammation has been consis...
Our results showed that hypoxia also induced the secretion of IL-1尾 in PC3, BPH-1 and RWPE-1 cells. Third, we found that NLRP3 inflammasome activation involved in regulating tumor growth and metastasis. Our results indicated that the activation of NLRP3 inflammation plays an important role ...
Table 1 Role of NLRP3 inflammasome activation or suppression in cancer development Full size table Role of the NLRP3 inflammasome in colonic epithelium homeostasis The inflammasome complex is a vital homeostatic component in the intestinal epithelium. Experimental mice models have highlighted the clinical...
炎性小体是先天免疫系统的重要组成成分,其中研究热点为NLRP3炎性小体,通过激活相应的信号途径参与多种慢性炎症疾病的发生发展。近年来NLRP3炎性小体在动脉粥样硬化、非酒精性脂肪性肝病、阿尔茨海默症、慢性阻塞性肺疾病和慢性肾脏病等疾病的发生进程中,发挥重要作用。本文将就炎性小体与慢性炎症相关疾病的研究进展进行...
role during the pathophysiology of neuroinflammation in age-related neurodegenerative diseases such as Parkinson’s (PD) and Alzheimer’s (AD). The neurotransmitter dopamine (DA) is one of the players that negatively modulate NLRP3 inflammasome activation through DA receptors expressed in both microglia...
There are different types of inflammasomes, although the nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 3 (NLRP3) inflammasome is the most common inflammasome; NLRP3 plays an important role in the pathogenesis of neurodegenerative diseases. In this review, we will ...
NLRP3 inflammasome regulates the caspase-1-dependent release of interleukin-1尾 and mediates inflammation in various diseases. Here, we investigated the role of NLRP3 inflammasome in a murine model of PD-related peritoneal fibrosis induced by methylglyoxal (MGO). Inflammasome-related proteins were up...
Bauernfeind, F. et al. Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome.J. Immunol.187, 613–617 (2011). CASPubMedGoogle Scholar Kool, M. et al. An unexpected role for uric acid as an inducer of T helper 2 cell immunity to...