NLRP3 is considered to be a sensor of microbial and other danger signals and plays a crucial role in immune responses, dysregulation of NLRP3 inflammasome activation is involved in skin diseases. With the in-depth research, targeting NLRP3 inflammasome and its downstream signaling will provide new...
An intense, stereotyped inflammatory response occurs in response to ischaemic and non-ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome is a finely regulated macromolecular protein complex that s
Our results showed that hypoxia also induced the secretion of IL-1尾 in PC3, BPH-1 and RWPE-1 cells. Third, we found that NLRP3 inflammasome activation involved in regulating tumor growth and metastasis. Our results indicated that the activation of NLRP3 inflammation plays an important role ...
Objective This article aims to provide an overview of studies reported in the literature investigating the pathological role of astrocyte involvement during the inflammatory response in hyperoxia-induced brain injury, the mechanisms of hyperoxia activateing the NLRP3 inflammasome to mediate pyroptosis in as...
The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human health. Researchers are dedicated to understanding and coping with the complexities of aging, constantly uncovering the substances and m
The role of NLRP3 inflammasome in aging and age-related diseasesRuikai Liang, Xinrui Qi, Qi Cai, Liyan Niu, Xi Huang, Deju Zhang, Jitao Ling, Yuting Wu, Yixuan Chen, Pingping Yang, Jianping Liu, Jing Zhang & Peng Yu ...
Table 1 Role of NLRP3 inflammasome activation or suppression in cancer development Full size table Role of the NLRP3 inflammasome in colonic epithelium homeostasis The inflammasome complex is a vital homeostatic component in the intestinal epithelium. Experimental mice models have highlighted the clinical...
The role of the NLRP3 inflammasome in gout Gout is an inflammatory arthritis characterized by abrupt self-limiting attacks of inflammation caused by precipitation of monosodium urate crystals (MSU) ... SR Kingsbury,PG Conaghan,MF Mcdermott - 《J Inflamm Res》 被引量: 178发表: 2011年 The role...
Among them, the NLR family pyrin domain containing 3 (NLRP3) inflammasome has been studied the most, and the specific mechanisms of its activation and regulation are complex [17], [18], [19]. Studies have shown that the NLRP3 inflammasome plays an important role in the digestive, ...
Inflammasomes play a vital role in inflammatory responses. They activate immune responses by releasing cytokines and inducing pyroptosis [1,2]. The NOD, LRR, and pyrin domain-containing protein 3 (NLRP3) is an essential inflammasome of immune response and can be activated by various stimuli [3]...